The influence of B vitamins, copper and uridine monophosphate on the functioning of the nervous system Review article
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Published:
Jun 30, 2023
Keywords:
methylcobalamin, methyltetrahydrofolate, copper, deficiencies, nervous system, uridine, B vitamins
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Abstract
For proper functioning nervous tissue requires many compounds that either participate in the metabolism of neurons or protect them from neurotoxicity. Some nutrients act simultaneously on both levels and their deficiencies require supplementation. Also in the course of pathological conditions affecting the nervous system, the administration of these substances may prove to be an effective and easy way to support therapy.
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Rudnicka, M. (2023). The influence of B vitamins, copper and uridine monophosphate on the functioning of the nervous system. Medycyna Faktow (J EBM), 16(2(59), 237-241. https://doi.org/10.24292/01.MF.0223.17
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References
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12. Okada K, Tanaka H, Temporin K et al. Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol. 2010; 222(2): 191-203.
13. Li Y, Zheng J, Zhu Y et al. Neuroprotective effects of methylcobalamin in cerebral ischemia/reperfusion injury through activation of the ERK1/2 signaling pathway. Int Immunopharmacol. 2021; 99: 108040.
14. Corejová A, Fazekaš T, Jánošíková D et al. Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration. Nutrients. 2022; 14: 2035.
15. Julian T, Syeed R, Glascow N et al. B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review. Nutrients. 2020; 12: 2221.
16. Didangelos T, Karlafti E, Kotzakioulaf E et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo- Controlled Trial. Nutrients. 2021; 13: 395.
17. Obeid R, Schön C, Pietrzik K et al. Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts. Nutrients. 2020; 12(12): 3623.
18. Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010; 49(8): 535-48.
19. Prinz-Langenohl R, Brämswig S, Tobolski O et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C,T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009; 158: 2014-21.
20. Ledowsky CJ, Schloss J, Steel A. Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study. Explor Res Clin Soc Pharm. 2023; 10: 100277.
21. Kumar N, Gross Jr JB, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology. 2004; 63(1): 33-9.
22. Benkirane A, Warlop T, Ivanoiu A. Case report: Motor neuron disease phenotype associated with symptomatic copper deficiency: Challenging diagnosis and treatment. Front Neurol. 2023; 13: 1063803.
23. Klevay LM. Alzheimer’s disease as copper deficiency. Med Hypotheses. 2008; 70(4): 802-7.
24. Dobolyi A, Juhász G, Kovács Z et al. Uridine function in the central nervous system. Curr Top Med Chem. 2011; 11(8): 1058-67.
25. Cakir A, Esmerce BO, Aydin B et al. Effects of uridine administration on hippocampal matrix metalloproteinases and their endogenous inhibitors in REM sleep-deprived rats. Brain Res. 2022; 1793: 148039.
26. Al-Otaibi A, AlAyed A, Al Madhi A et al. Uridine monophosphate (UMP)-responsive developmental and epileptic encephalopathy: A case report of two siblings and a review of literature. Mol Genet Metab Rep. 2022; 30: 100835.
27. Negrão L, Almeida P, Alcino S et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag. 2014; 4(3): 191-6.
2. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy – A Review. Nutrients. 2016; 8: 68.
3. Calderón‐Ospina CA, Nava‐Msa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2020; 26: 5-13.
4. Jiang J, Wang Y, Deng M. New developments and opportunities in drugs being trialed for amyotrophic lateral sclerosis from 2020 to 2022. Front Pharmacol. 2022; 13: 1054006.
5. Gil Martínez V, Avedillo Salas A, Santander Ballestín S. Vitamin Supplementation and Dementia: A Systematic Review. Nutrients. 2022; 14: 1033.
6. Zając-Lamparska L. Kompensacyjna aktywność mózgu osób starszych. Gerontologia Polska. 2018; 26: 54-8.
7. Paul C, Brady DM. Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms. Integr Med. 2017; 16(1): 42-9.
8. Spence JD. Reducing the Risk of Stroke in Patients with Impaired Renal Function: Nutritional Issues. J Stroke Cerebrovasc Dis. 2021; 30(9): 105376.
9. Morales-Gutierrez J, Díaz-Cortés S, Montoya-Giraldo MA et al. Toxicity induced by multiple high doses of vitamin B12 during pernicious anemia treatment: a case report. Clin Toxicol (Phila). 2020; 58(2): 129-31.
10. Rossignol DA, Frye RE. The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. J Pers Med. 2021; 11: 784.
11. Zhang M, Han W, Hu S et al. Methylcobalamin: A Potential Vitamin of Pain Killer. Neural Plasticity. 2013; 424651.
12. Okada K, Tanaka H, Temporin K et al. Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol. 2010; 222(2): 191-203.
13. Li Y, Zheng J, Zhu Y et al. Neuroprotective effects of methylcobalamin in cerebral ischemia/reperfusion injury through activation of the ERK1/2 signaling pathway. Int Immunopharmacol. 2021; 99: 108040.
14. Corejová A, Fazekaš T, Jánošíková D et al. Improvement of the Clinical and Psychological Profile of Patients with Autism after Methylcobalamin Syrup Administration. Nutrients. 2022; 14: 2035.
15. Julian T, Syeed R, Glascow N et al. B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review. Nutrients. 2020; 12: 2221.
16. Didangelos T, Karlafti E, Kotzakioulaf E et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo- Controlled Trial. Nutrients. 2021; 13: 395.
17. Obeid R, Schön C, Pietrzik K et al. Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts. Nutrients. 2020; 12(12): 3623.
18. Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010; 49(8): 535-48.
19. Prinz-Langenohl R, Brämswig S, Tobolski O et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C,T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009; 158: 2014-21.
20. Ledowsky CJ, Schloss J, Steel A. Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study. Explor Res Clin Soc Pharm. 2023; 10: 100277.
21. Kumar N, Gross Jr JB, Ahlskog JE. Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration. Neurology. 2004; 63(1): 33-9.
22. Benkirane A, Warlop T, Ivanoiu A. Case report: Motor neuron disease phenotype associated with symptomatic copper deficiency: Challenging diagnosis and treatment. Front Neurol. 2023; 13: 1063803.
23. Klevay LM. Alzheimer’s disease as copper deficiency. Med Hypotheses. 2008; 70(4): 802-7.
24. Dobolyi A, Juhász G, Kovács Z et al. Uridine function in the central nervous system. Curr Top Med Chem. 2011; 11(8): 1058-67.
25. Cakir A, Esmerce BO, Aydin B et al. Effects of uridine administration on hippocampal matrix metalloproteinases and their endogenous inhibitors in REM sleep-deprived rats. Brain Res. 2022; 1793: 148039.
26. Al-Otaibi A, AlAyed A, Al Madhi A et al. Uridine monophosphate (UMP)-responsive developmental and epileptic encephalopathy: A case report of two siblings and a review of literature. Mol Genet Metab Rep. 2022; 30: 100835.
27. Negrão L, Almeida P, Alcino S et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag. 2014; 4(3): 191-6.