Anti-ischaemic properties of new β-blockers on the example of nebivolol Review article
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Abstract
β-blockers are drugs widely used in the treatment of coronary artery disease. The principal mechanisms of action of this class of drugs are: reduction of heart rate and myocardial contractility and decrease in systemic blood pressure, which in turn translates into a decrease in myocardial oxygen demand, improved control of angina symptoms and improved patients prognosis. Properties mentioned above were already possessed by the first generation of β-blockers. However, next generations of β-blockers brought modifications aiming to improve the safety profile, reduce adverse effects and strengthen the desired effects of therapy. As a result, the impact of β-blockers on: coronary flow regulation, lipid metabolism and insulin resistance have improved. The following article elaborates scientific evidence about the beneficial effects of third generation of β-blockers in the treatment of coronary artery disease. Nebivolol has recently been registered for use in stable coronary artery disease, hence will be used as an example of the third class of β-blockers in this article.
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