Can you always split tablets? Review article
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Published:
Dec 31, 2016
Keywords:
splitting tablets, delayed-release tablets, therapeutic dose
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Abstract
Patients often split their tablets for certain reasons. Primarily to make the intake easier. They also do so for economical reasons and to make pill doses smaller. We have to remember, that splitting tablets might interfere their structure and pharmacokinetic properties, which in consequence can lead to the lack of gaining the intended therapeutical effect. Tablets can be split only if there is an information in Summary of Product Characteristic.
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How to Cite
Komorniczak, T., & Mamcarz , A. (2016). Can you always split tablets?. Medycyna Faktow (J EBM), 9(4(33), 353-356. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2212
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References
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2. Shah R.B., Collier J.S., Sayeed V.A. et al.: Tablet Splitting of a Narrow Therapeutic Index Drug: A Case with Levothyroxine Sodium. AAPS PharmSci- Tech. 2010; 11(3): 1359-1367.
3. Verrue C., Mehuys E., Boussery K. et al.: Tablet-splitting: a common yet not so innocent practice. J. Adv. Nurs. 2011; 67(1): 26-32.
4. Clark T.R.: Tablet splitting for cost containment. American Society of Consultant Pharmacists 2002.
5. Chou C.L., Hsu C.C., Chou C.Y. et al.: Tablet splitting of narrow therapeutic index drugs: a nationwide survey in Taiwan. Int. J. Clin. Pharm. 2015; 37(6): 1235-1241.
6. Marriott J.L., Nation R.L.: Splitting tablets. Aust. Prescr. 2002; 25(6): 133-135.
7. Foster H.: Why crushing your pills to make them easier to swallow could give you an overdose, and other medicine mishaps to avoid. Daily Mail. 11.03.2014.
8. Wisłowska M.: Przewlekłe stosowanie NLPZ – zagrożenia, potencjalne powikłania. Medycyna Rodzinna 2004; 1: 22-26.
9. Dammann H.G., Burkhardt F., Wolf N.: Enteric coating of aspirin significantly decreases gastroduodenal mucosal lesions. Aliment. Pharmacol. Ther. 1999; 13(8): 1109-1114.
10. Hawkins C., Hanks G.W.: The Gastroduodenal Toxicity of Nonsteroidal Anti-Inflammatory Drugs. A Review of the Literature. J. Pain Symptom. Manage. 2000; 20(2): 140-151.
11. Kikendall J.W.: Pill-Induced Esophagitis. Gastroenterol. Hepatol. (NY) 2007; 3(4): 275-276.
12. Sawicki W., Łepek P., Kleina M.: Otoczki na tabletkach i peletkach – budowa, funkcja, mechanizm i metody powlekania. Farm. Pol. 2012; 66(5): 378-382.
13. Karaman R.: Prodrugs for Masking the Bitter Taste of Drugs, Application of Nanotechnology in Drug Delivery. Sezer A.D. (red.). InTech 2014 [doi: 10.5772/58404].
14. Root T., Tomlin S., Erskine D. et al.: Pharmaceutical Issues when Crushing, Opening or Splitting Oral Dosage Forms. Royal Pharmaceutical Society 2011.