Clinical cases of patients treated with tadalafil and solifenacin Case report

Abstract

The article presents the principles of therapy with two urological drugs – tadalafil and solifenacin. Three clinical cases discussing their practical application were also presented. The first drug is mainly used in the treatment of erectile dysfunction and prostate hypertrophy, the second in the treatment of urgent urinary incontinence and overactive bladder syndrome. The action of tadalafil is based on selective and reversible inhibition of specific phosphodiesterase of cGMP type 5. Its inhibition by tadalafil leads to cGMP concentration in cavernous bodies, which prolongs the relaxation of smooth muscles and blood flow to the tissues of penis, thus helps to obtain and maintain erection. In this indication, the drug is used temporarily, no more often than 1–2 times a week. In the management of benign prostatic hyperplasia, treatment is based on lower doses of tadalafil, but taken daily.

The diagnosis of overactive bladder syndrome requires, collection of medical history, while an urodynamic examination is not necessary. In therapy, we use anticholinergic drugs, one of them is solifenacin. The drug is characterized by high affinity for the M3 and M muscarinic receptors located in the bladder and urethra. This feature lies at the root of good tolerance of solifenacin by patients. Diagnosis and treatment of both discussed disorders is the competence of family doctors, they have the full right to diagnose the problem, make a diagnosis and initiate adequate therapy.