Patient with relapsing-remitting multiple sclerosis diagnosed with familial Mediterranean fever – case report Case report
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Abstract
A patient with multiple sclerosis symptoms which started at 18 years of age and who received immunomodulating treatment initially with interferon β-1a, and subsequently with dimethyl fumarate, presented recurring fever of unknown origin. Serum inflammation markers were negative. Because of those symptoms the patient underwent extensive diagnostics which revealed several non-specific abnormalities. Multiple sclerosis treatment was temporarily halted. Corticosteroids and immunosuppressants lead to partial improvement of the patient’s condition. Eventually the patient was referred to genetic testing which showed genetic predisposition towards familial Mediterranean fever, and colchicine treatment was initiated.
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References
2. Dobson R, Giovannoni G. Multiple sclerosis – a review. Eur J Neurol. 2019; 26: 27-40.
3. Nelson DA, McDowell DF. The effects of induced hyperthermia on patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 1959; 22: 113-6.
4. Andersen EB, Nordenbo AM. Sympathetic vasoconstrictor responses in multiple sclerosis with thermo-regulatory dysfunction. Clin Auton Res. 1997; 7: 13-6.
5. Jacobs LD, Cookfair DL, Rudick RA et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol. 1996; 39: 285-94.
6. Rowczenio DM, Iancu DS, Trojer H et al. Autosomal dominant familial Mediterranean fever in Northern European Caucasians associated with deletion of p.M694 residue – a case series and genetic exploration. Rheumatology (Oxford). 2017; 56(2): 209-13.
7. Stoffman N, Magal N, Shohat T et al. Higher than expected carrier rates for familial Mediterranean fever in various Jewish ethnic groups. Eur J Hum Genet. 2000; 8(4): 307-10.
8. Papadopoulos V, Mitroulis I, Giaglis S. MEFV heterogeneity in Turkish Familial Mediterranean Fever patients. Mol Biol Rep. 2010; 37(1): 355-8.
9. Bakkaloglu A. Familial Mediterranean fever. Pediatr Nephrol. 2003; 18: 853-9.
10. Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet. 1998; 351(9103): P659-664.
11. Yepiskoposyan L, Harutyunyan A. Population genetics of familial Mediterranean fever: a review. Eur J Hum Genet. 2007; 15: 911-6.