A patient with Creutzfeldt-Jakob disease – a case report Case report

Abstract

Creutzfeldt-Jakob diesease is a fatal neurodegenerative disorder caused by protein called prion, which as a normal prion protein converted into a disease-related isoform. Sporadic CJD is a most common form of the disease and is estimated at about 90% of all recognized CJD cases. Due to heterogenous clinical presentation the disease is difficult to diagnose. This articule presents a clinical case of the patient hospitalized at the Neurology Department at a specialist hospital in Wrocław, Poland. The standard diagnostic procedure available in Poland were used in this case. The 14-3-3 protein released into the cerebrospinal fluid can be found in a number of different neurological disorders compared to a RT-QuIC – high diagnostic value analysis – that detects an abnormal prion protein and is a specific marker for CJD with its sensivity at 85% and its specificity at 100%.