Amlodypina – state of art Artykuł przeglądowy
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Opublikowane:
cze 30, 2013
Słowa kluczowe:
amlodypina, nadciśnienie tętnicze, medycyna oparta na faktach, wskazania
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Abstrakt
Amlodypina to pochodna dihydropirydyny blokująca kanały wapniowe typu L, głównie w ścianie tętnic. Ma działanie hipotensyjne i przeciwdławicowe. Jej zaletami są długi czas działania (możliwość dawkowania raz dziennie) i neutralność metaboliczna. Wskazania do terapii obejmują: nadciśnienie tętnicze (w monoterapii lub leczeniu skojarzonym) oraz objawowe leczenie choroby niedokrwiennej serca, w tym dławicy Prinzmetala. Może być stosowana jako lek hipotensyjny lub przeciwdławicowy w przewlekłej niewydolności serca. W terapii skojarzonej szczególnie zalecane jest połączenie amlodypiny z inhibitorem konwertazy angiotensyny. Badania kliniczne potwierdziły skuteczność hipotensyjną amlodypiny, a także wykazały jej znaczenie w redukcji częstości powikłań sercowo-naczyniowych.
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Jak cytować
Wydra, W., & Kuch , M. (2013). Amlodypina – state of art . Medycyna Faktów , 6(2(19), 7-14. Pobrano z https://journalsmededu.pl/index.php/jebm/article/view/2409
Numer
Dział
Artykuły
Copyright © by Medical Education. All rights reserved.
Bibliografia
1. Bahl V.K., Jadhav U.M., Thacker H.P.: Management of hypertension with the fixed combination of perindopril and amlodipine in daily clinical practice: results from the STRONG prospective, observational, multicenter study. Am. J. Cardiovasc. Drugs 2009; 9(3): 135-42.
2. Boutouyrie P., Achouba A., Trunet P. et al.; for the EXPLOR Trialist Group: Amlodipine-Valsartan Combination Decreases Central Systolic Blood Pressure More Effectively Than the Amlodipine-Atenolol Combination. The EXPLOR Study. Hypertension 2010; 55: 1314-1322.
3. Byington R.P., Miller M.E., Herrington D. et al.; for the PREVENT Investigators: Rationale, design and baseline characteristics of the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT). Am. J. Cardiol. 1997; 80: 1087-1090.
4. Chrysant S.G., Melino M., Karki S. et al.: The Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure: COACH, a Randomized, Double-Blind, Placebo-Controlled, 8-Week Factorial Efficacy and Safety Study. Clin. Ther. 2008; 30: 587-604.
5. Czarnecka D., Bednarek A.: Amlodypina – idealny lek w terapii skojarzonej w nadciśnieniu tętniczym. Medycyna Faktów 2012; 1(14): 43-48.
6. Dahlof B., Sever P.S., Poulter N.R. et al.: Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895-906.
7. Fox K., Alonso Garcia M.A., Ardissino D. et al.: Guidelines on the management of stable angina pectoris: executive summary: the Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur. Heart J. 2006; 27: 1341-81.
8. Grobbee D.E., Bots M.L.: Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J. Intern. Med. 1994; 236: 567-573.
9. Jamerson K., Weber M.A., Bakris G.L. et al.; ACCOMPLISH trial investigators: Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N. Engl. J. Med. 2008; 359: 2417-2428.
10. Januszewicz A., Prejbisz A.: Miejsce inhibitorów konwertazy angiotensyny i antagonistów wapnia w terapii nadciśnienia tętniczego. Medical Education 2012.
11. Jorgensen B., Simonsen S., Endresen K. et al.: Restenosis and clinical outcomes in patients treated with amlodipine after angioplasty: results from Coronary AngioPlasty Amlodipine REstenosis Study (CAPARES). J. Am. Coll. Cardiol. 2000; 35: 592-599.
12. Julius S., Kjeldsen S.E., Weber M. et al.: VALUE trial group: Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004; 363(9426): 2022-31.
13. Ko Y., Totzke G., Graack G.H. et al.: Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells. J. Hypertens. 1993; 11: 1171-1178.
14. Neaton J.D., Grimm R.H., Prineas R.J. et al.: Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group. JAMA 1993; 270: 713-724.
15. Nissen S.E., Tuzcu E.M., Libby P. et al.; for the CAMELOT Investigators: Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: The CAMELOT study: a randomized controlled trial. JAMA 2004; 292: 2217-2226.
16. Mancia G., Fagard R., Narkiewicz K. et al.: 2013 ESH/ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). European Heart Journal 2013; 151: 1-72.
17. Mason R.P.: Cytoprotective properties of a long-acting calcium channel blocker: new mechanism of action. Am. J. Hypertens. 1998; 11: 245A-249A.
18. Matsushita K., Muramatsu T., Kondo T. et al.: Rationale and design of the NAGOYA HEART Study: comparison between valsartan and amlodipine regarding morbidity and mortality in patients with hypertension and glucose intolerance. J. Cardiol. 2010; 56: 111-7.
19. O’Connor C.M., Carson P.E., Miller A.B. et al.: Effect of amlodipine on mode of death among patients with advanced heart failure in the PRAISE trial. Prospective Randomized Amlodipine Survival Evaluation. Am. J. Cardiol. 1998; 82(7): 881-7.
20. Pitt B., Byington R.P., Furberg C.D. et al.: Effect of amlodipine on the progression of atherosclerosis and the occurance of clinical events. Circulation 2000; 26: 1503-1510.
21. Reichek N., Devereux R.B, Rocha R.A. et al.: Magnetic Resonance Imaging Left Ventricular Mass Reduction With Fixed-Dose Angiotensin-Converting Enzyme Inhibitor-Based Regimens in Patients With High-Risk Hypertension. Hypertension 2009; 54: 731-737.
22. Tulenko T.N., Laury-Kleintop L., Walter M.F. et al.: Cholesterol, calcium and atherosclerosis: is there a role for calcium channel blockers in atheroprotection? Int. J. Cardiol. 1997; 62(supl. 2): 55S-66S.
23. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group: Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981-2997.
24. Widecka K., Grodzicki T., Narkiewicz K. et al.: Zasady postępowania w nadciśnieniu tętniczym – 2011 rok. Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego. Nadciśnienie Tętnicze 2011; 15: 211-235.
25. Williams B., Lacy P.S., Thom S.M. et al.: Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006; 113: 1213-1225.
26. Zhang X., Hintze T.H.: Amlodypine releases nitric oxide from canine coronary microvessels: an unexpected mechanism of action of a calcium channel-blocking agent. Circulation 1998; 97: 576-580.
2. Boutouyrie P., Achouba A., Trunet P. et al.; for the EXPLOR Trialist Group: Amlodipine-Valsartan Combination Decreases Central Systolic Blood Pressure More Effectively Than the Amlodipine-Atenolol Combination. The EXPLOR Study. Hypertension 2010; 55: 1314-1322.
3. Byington R.P., Miller M.E., Herrington D. et al.; for the PREVENT Investigators: Rationale, design and baseline characteristics of the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT). Am. J. Cardiol. 1997; 80: 1087-1090.
4. Chrysant S.G., Melino M., Karki S. et al.: The Combination of Olmesartan Medoxomil and Amlodipine Besylate in Controlling High Blood Pressure: COACH, a Randomized, Double-Blind, Placebo-Controlled, 8-Week Factorial Efficacy and Safety Study. Clin. Ther. 2008; 30: 587-604.
5. Czarnecka D., Bednarek A.: Amlodypina – idealny lek w terapii skojarzonej w nadciśnieniu tętniczym. Medycyna Faktów 2012; 1(14): 43-48.
6. Dahlof B., Sever P.S., Poulter N.R. et al.: Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: 895-906.
7. Fox K., Alonso Garcia M.A., Ardissino D. et al.: Guidelines on the management of stable angina pectoris: executive summary: the Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur. Heart J. 2006; 27: 1341-81.
8. Grobbee D.E., Bots M.L.: Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J. Intern. Med. 1994; 236: 567-573.
9. Jamerson K., Weber M.A., Bakris G.L. et al.; ACCOMPLISH trial investigators: Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N. Engl. J. Med. 2008; 359: 2417-2428.
10. Januszewicz A., Prejbisz A.: Miejsce inhibitorów konwertazy angiotensyny i antagonistów wapnia w terapii nadciśnienia tętniczego. Medical Education 2012.
11. Jorgensen B., Simonsen S., Endresen K. et al.: Restenosis and clinical outcomes in patients treated with amlodipine after angioplasty: results from Coronary AngioPlasty Amlodipine REstenosis Study (CAPARES). J. Am. Coll. Cardiol. 2000; 35: 592-599.
12. Julius S., Kjeldsen S.E., Weber M. et al.: VALUE trial group: Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004; 363(9426): 2022-31.
13. Ko Y., Totzke G., Graack G.H. et al.: Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells. J. Hypertens. 1993; 11: 1171-1178.
14. Neaton J.D., Grimm R.H., Prineas R.J. et al.: Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group. JAMA 1993; 270: 713-724.
15. Nissen S.E., Tuzcu E.M., Libby P. et al.; for the CAMELOT Investigators: Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: The CAMELOT study: a randomized controlled trial. JAMA 2004; 292: 2217-2226.
16. Mancia G., Fagard R., Narkiewicz K. et al.: 2013 ESH/ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). European Heart Journal 2013; 151: 1-72.
17. Mason R.P.: Cytoprotective properties of a long-acting calcium channel blocker: new mechanism of action. Am. J. Hypertens. 1998; 11: 245A-249A.
18. Matsushita K., Muramatsu T., Kondo T. et al.: Rationale and design of the NAGOYA HEART Study: comparison between valsartan and amlodipine regarding morbidity and mortality in patients with hypertension and glucose intolerance. J. Cardiol. 2010; 56: 111-7.
19. O’Connor C.M., Carson P.E., Miller A.B. et al.: Effect of amlodipine on mode of death among patients with advanced heart failure in the PRAISE trial. Prospective Randomized Amlodipine Survival Evaluation. Am. J. Cardiol. 1998; 82(7): 881-7.
20. Pitt B., Byington R.P., Furberg C.D. et al.: Effect of amlodipine on the progression of atherosclerosis and the occurance of clinical events. Circulation 2000; 26: 1503-1510.
21. Reichek N., Devereux R.B, Rocha R.A. et al.: Magnetic Resonance Imaging Left Ventricular Mass Reduction With Fixed-Dose Angiotensin-Converting Enzyme Inhibitor-Based Regimens in Patients With High-Risk Hypertension. Hypertension 2009; 54: 731-737.
22. Tulenko T.N., Laury-Kleintop L., Walter M.F. et al.: Cholesterol, calcium and atherosclerosis: is there a role for calcium channel blockers in atheroprotection? Int. J. Cardiol. 1997; 62(supl. 2): 55S-66S.
23. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group: Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981-2997.
24. Widecka K., Grodzicki T., Narkiewicz K. et al.: Zasady postępowania w nadciśnieniu tętniczym – 2011 rok. Wytyczne Polskiego Towarzystwa Nadciśnienia Tętniczego. Nadciśnienie Tętnicze 2011; 15: 211-235.
25. Williams B., Lacy P.S., Thom S.M. et al.: Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006; 113: 1213-1225.
26. Zhang X., Hintze T.H.: Amlodypine releases nitric oxide from canine coronary microvessels: an unexpected mechanism of action of a calcium channel-blocking agent. Circulation 1998; 97: 576-580.