Efficacy and safety of combination therapy: valsartan and sustained-release indapamide Review article
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Published:
Jun 30, 2025
Keywords:
hypertension, valsartan, indapamide, single-pill combination, monotherapy
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Abstract
According to the 2024 guidelines of the European Society of Cardiology, the treatment of arterial hypertension should be based on combination therapy, preferably in the form of a single-pill combination, which improves both treatment efficacy and patient adherence. The combination of valsartan (an angiotensin II receptor blocker) with sustained-release indapamide (a thiazide-like diuretic) offers complementary antihypertensive mechanisms while maintaining a favourable safety and metabolic profile, and providing additional renal- and cardioprotective effects. These benefits have been confirmed in high-risk populations, including patients with cardiovascular diseases and elderly individuals. The valsartan + sustained-release indapamide combination represents a modern and effective therapeutic option in the treatment of arterial hypertension.
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Skwarek, A., & Ozierański, K. (2025). Efficacy and safety of combination therapy: valsartan and sustained-release indapamide. Medycyna Faktow (J EBM), 18(2(67), 271-275. https://doi.org/10.24292/01.MF.0225.15
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References
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13. Ambrosioni E, Safar M, Degaute JP et al. Low-dose antihypertensive therapy with 1.5 mg sustained-release indapamide: results of randomised double-blind controlled studies. European study group. J Hypertens. 1998; 16(11): 1677-84.
14. Ames RP. A comparison of blood lipid and blood pressure responses during the treatment of systemic hypertension with indapamide and with thiazides. Am J Cardiol. 1996; 77(6): 12b-6b.
2. Byrne RA, Rossello X, Coughlan JJ et al. 2023 ESC Guidelines for the management of acute coronary syndromes: Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC). Eur Heart J. 2023; 44(38): 3720-826.
3. McDonagh TA, Metra M, Adamo M et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2021; 42(36): 3599-726.
4. Black HR, Graff A, Shute D et al. Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy, tolerability and safety compared to an angiotensin-converting enzyme inhibitor, lisinopril. J Hum Hypertens. 1997; 11(8): 483-9.
5. Holwerda NJ, Fogari R, Angeli P et al. Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: efficacy and safety compared with placebo and enalapril. J Hypertens. 1996; 14(9): 1147-51.
6. Hanefeld M, Abletshauser C. Effect of the angiotensin II receptor antagonist valsartan on lipid profile and glucose metabolism in patients with hypertension. J Int Med Res. 2001; 29(4): 270-9.
7. Julius S, Weber MA, Kjeldsen SE et al. The Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial: outcomes in patients receiving monotherapy. Hypertension. 2006; 48(3): 385-91.
8. Hollenberg NK, Parving HH, Viberti G et al. Albuminuria response to very high-dose valsartan in type 2 diabetes mellitus. J Hypertens. 2007; 25(9): 1921-6.
9. Pfeffer MA, McMurray JJ, Velazquez EJ et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003; 349(20): 1893-906.
10. Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med. 2001; 345(23): 1667-75.
11. Beckett NS, Peters R, Fletcher AE et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008; 358(18): 1887-98.
12. Emeriau JP, Knauf H, Pujadas JO et al.; European Study Investigators. A comparison of indapamide SR 1.5 mg with both amlodipine 5 mg and hydrochlorothiazide 25 mg in elderly hypertensive patients: a randomized double-blind controlled study. J Hypertens. 2001; 19(2): 343-50.
13. Ambrosioni E, Safar M, Degaute JP et al. Low-dose antihypertensive therapy with 1.5 mg sustained-release indapamide: results of randomised double-blind controlled studies. European study group. J Hypertens. 1998; 16(11): 1677-84.
14. Ames RP. A comparison of blood lipid and blood pressure responses during the treatment of systemic hypertension with indapamide and with thiazides. Am J Cardiol. 1996; 77(6): 12b-6b.