Recurrent urinary tract infections in a 6-year-old girl – treatment with cefixime and furazidine – case report and literature review Case report

Article Sidebar

Requires Subscription PDF (Język Polski)
Purchase article

Published: Jun 30, 2023
DOI: https://doi.org/10.24292/01.MF.0223.24
Keywords:
urinary tract infection, acute pyelonephritis, acute cystitis, children, cefixime, furazidine

Main Article Content

Piotr Skrzypczyk
Katedra i Klinika Pediatrii i Nefrologii, Warszawski Uniwersytet Medyczny

Abstract

Urinary tract infections are the most common bacterial infections in children. Proper diagnosis and treatment of urinary tract infections allows for faster cure of the disease and prevention of complications. This article presents a case report of a 6-year-old girl in whom urinary tract infections were successfully treated with cefixime and furazidine. Cefixime is a third-generation oral cephalosporin with broad-spectrum bactericidal activity and a good safety profile, which is used in the treatment of pyelonephritis, cystitis, and also the prevention of recurrent urinary tract infections. Furazidine is a widely used chemotherapeutic agent from the group of furan derivatives with a multi-target effect on the bacterial cell, indicated for the treatment of cystitis and prevention of urinary tract infections. This article discusses data from clinical trials indicating the benefit of these drugs in children with urinary tract infections.

Article Details

How to Cite
Skrzypczyk, P. (2023). Recurrent urinary tract infections in a 6-year-old girl – treatment with cefixime and furazidine – case report and literature review. Medycyna Faktow (J EBM), 16(2(59), 278-282. https://doi.org/10.24292/01.MF.0223.24
Issue
Vol 16 No 2(59) (2023)
Section
Articles

Copyright © by Medical Education. All rights reserved.

References

1. Wasilewska A, Zurowska A, Jung A et al. Zalecenia Polskiego Towarzystwa Nefrologii Dziecięcej (PTNFD) dotyczące postępowania z dzieckiem z zakażeniem układu moczowego. Uniwersytet Medyczny w Białymstoku, Białystok 2021.
2. Tullus K, Shaikh N. Urinary tract infections in children. Lancet. 2020; 395: 1659-68.
3. Brandström P, Hansson S. Urinary Tract Infection in Children. Pediatr Clin North Am. 2022; 69: 1099-114.
4. Schwartz GJ, Muñoz A, Schneider MF et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009; 20: 629-37.
5. Cetix, 100 mg/5 ml, granulat do sporządzania zawiesiny doustnej. Ulotka dołączona do opakowania (access: 8.05.2023).
6. Mamzoridi K, Kasteridou N, Peonides A et al. Pharmacokinetics of cefixime in children with urinary tract infections after a single oral dose. Pharmacol Toxicol. 1996; 78: 417-20.
7. Cetix, 400 mg, tabletki powlekane. Ulotka dołączona do opakowania (access: 8.05.2023).
8. Dagan R, Einhorn M, Lang R et al. Once daily cefixime compared with twice daily trimethoprim/sulfamethoxazole for treatment of urinary tract infection in infants and children. Pediatr Infect Dis J. 1992; 11: 198-203.
9. François P, Croizé J, Bost C et al. [Comparative study of cefixime versus amoxicillin-clavulanic acid combination in the oral treatment of urinary tract infections in children]. Arch Pediatr. 1995; 2: 136-42.
10. Hoberman A, Wald ER, Hickey RW et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999; 104: 79-86.
11. Gok F, Duzova A, Baskin E et al. Comparative study of cefixime alone versus intramuscular ceftizoxime followed by cefixime in the treatment of urinary tract infections in children. J Chemother. 2001; 13: 277-80.
12. Stranieri G, Zampogna S, Ielapi V et al. Cefixime for the prophylaxis of urinary tract infections in children with malformative uropathies: an open study. Eur Rev Med Pharmacol Sci. 2003; 7: 57-64.
13. Lettgen B, Tröster K. [Prophylaxis of recurrent urinary tract infections in children. Results of an open, controlled and randomized study about the efficacy and tolerance of cefixime compared to nitrofurantoin]. Klin Padiatr. 2002; 214: 353-8.
14. Fanos V, Cataldi L. Cefixime in urinary tract infections with special reference to pediatrics: overview. J Chemother. 2001; 13: 112-7.
15. Giske CG. Contemporary resistance trends and mechanisms for the old antibiotics colistin, temocillin, fosfomycin, mecillinam and nitrofurantoin. Clin Microbiol Infect. 2015; 21: 899-905.
16. Dafurag junior 10 mg/ml, zawiesina doustna. Ulotka dołączona do opakowania (access: 8.05.2023).
17.Dafurag max, 100 mg, tabletki. Ulotka dołączona do opakowania (access: 8.05.2023).
18. Klesiewicz K, Karczewska E, Nowak P et al. Comparative in vitro studies of furazidin and nitrofurantoin activities against common uropathogens including multi-drug resistant strains of E. coli and S. aureus. Acta Pol Pharm. 2018; 75: 803-12.
19. Werbel K, Jankowska D, Wasilewska A et al. Clinical and Epidemiological Analysis of Children’s Urinary Tract Infections in Accordance with Antibiotic Resistance Patterns of Pathogens. J Clin Med. 2021; 10: 5260.
20. Williams G, Craig JC. Long-term antibiotics for preventing recurrent urinary tract infection in children. Cochrane Database Syst Rev. 2019; 4: Cd001534.