Loop diuretics – torasemide Review article
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Abstract
Torasemide is the youngest representative of loop diuretics with a strong natriuretic activity. Torasemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2 CI--carrier system. Torasemide increases the urinary excretion of sodium, chloride, potassium, magnesium, calcium and water. It has additional pharmacokinetic properties that distinguish it from other loop diuretics: longer period of activity, higher bioavailability, anti-aldosterone activity, metabolic neutrality. Torasemide potency is four times higher than that of furosemide. Torasemide is indicated for the treatment of hypertension and edema associated with congestive heart failure, renal disease, and hepatic disease. Clinical studies have shown that torasemide in comparison with other loop diuretics improves left ventricular function and exercise capacity and quality of life in heart failure.
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References
2. Müller K., Gambab G., Jaquetc F., Hessd B.: Torasemide vs. furosemide in primary care patients with chronic heart failure NYHA II to IV – efficacy and quality of life. Eur. J. Heart Fail. 2003; 5(6): 793-801 [doi: 10.1016/S1388-9842(03)00150-8].
3. Friedel H.A., Buckley M.M.: Torasemide. A review of its pharmacological properties and therapeutic potential. Drugs 1991; 41(1): 81-103.
4. Wełnicki M., Mamcarz A.: Torasemid versus furosemid w leczeniu niewydolności serca. Kardioprofil 2011; 3: 176-171.
5. Murray M.D., Deer M.M., Ferguson J.A. et al.: Open-label randomized trial of torsemide compared with furosemide therapy for patients with heart failure. Am. J. Med. 2011 Nov; 111(7): 513-520.