Does concomitant aspirin use reduce effectiveness of angiotensin-converting-enzyme inhibitors after myocardial infarction? Review article

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Published: Sep 30, 2012
Keywords:
angiotensin converting enzyme inhibitors, aspirin, coronary artery disease, zofenopril

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Wioletta Dyrla
Division of Heart Failure and Cardiac Rehabilitation, Department of Cardiology, Hypertension and Internal Medicine, Second Medical Faculty, Warsaw Medical University
Agnieszka Wsół
Department of Experimental and Clinical Physiology, Medical University of Warsaw, Poland
Marek Kuch
Division of Heart Failure and Cardiac Rehabilitation, Department of Cardiology, Hypertension and Internal Medicine, Second Medical Faculty, Warsaw Medical University

Abstract

Aspirin and angiotensin converting enzyme (ACE) inhibitors are widely used in cardiology. Based on retrospective analysis of large clinical trials, researchers have suggested that aspirin may reduce the effectiveness of ACE inhibitors in patients with coronary artery disease or heart failure. The data is not sufficient to create a recommendation not to combine these drugs. A prospective randomized study SMILE-4 showed sustained positive effects of the ACE inhibitor, zofenopril which was used together with aspirin in acute myocardial infarction. Likely special properties of zofenopril, sulfhydryl containing ACEI are the cause of the persistence positive cardioprotective effect even in presence of cyclooxygenase inhibitors.

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How to Cite
Dyrla , W., Wsół, A., & Kuch, M. (2012). Does concomitant aspirin use reduce effectiveness of angiotensin-converting-enzyme inhibitors after myocardial infarction?. Medycyna Faktow (J EBM), 5(3(16), 12-16; 19. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2450
Issue
Vol 5 No 3(16) (2012)
Section
Articles

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