Duloxetine – possibilities of application in the practice of a psychiatrist – a pocket guide Review article
Article Sidebar
Main Article Content
Abstract
The aim of the article is to show, in clinical cases, the possibility of using duloxetine in the daily practice of a psychiatrist, neurologist and general practitioner, as well as to identify a patient profile that could benefit most from the therapy with this drug. The author summarized the information on the safety and indications for the use of duloxetine in the text, comparing this drug to other commonly used antidepressants. Based on the results of research and own experience in the use of duloxetine in various clinical situations and in various patient populations, the author also referred to the most frequently emerging questions and doubts that constitute a barrier to the implementation of duloxetine therapy by doctors.
Article Details
Copyright © by Medical Education. All rights reserved.
References
2. Arnold LM, Lu Y, Crofford LJ et al. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis Rheum. 2004; 50: 2974-84.
3. Arnold LM, Rosen A, Pritchett YL et al. A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder. Pain. 2005; 119: 5-15.
4. Perahia DG, Quail D, Desaiah D et al. Switching to duloxetine in selective serotonin reuptake inhibitor non- and partial-responders: effects on painful physical symptoms of depression. J Psychiatr Res. 2009a; 43: 512-8.
5. Raskin J, Wiltse CG, Siegal A et al. Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial. Am J Psychiatry. 2007; 164: 900-9.
6. Romera I, Pérez V, Menchón JM et al. Early vs. conventional switching of antidepressants in patients with MDD and moderate to severe pain: a double-blind randomized study. J Affect Disord. 2012; 143: 47-55.
7. Karp JF, Whyte EM, Lenze EJ et al. Rescue Pharmacotherapy with Duloxetine for SSRI Nonresponders in Late Life Depression: Outcome and Tolerability. J Clin Psychiatry. 2008; 69: 457-63.
8. Papakostas GI, Fava M, Thase ME et al. Treatment of SSRI-Resistant Depression: A Meta-analysis Comparing Within-Versus Across-Class Switches. Biol Psychiatry. 2008; 63: 699-74.
9. Derby MA, Zhang L, Chappell JC et al. The effects of supratherapeutic doses of duloxetine on blood pressure and pulse rate. J Cardiovasc Pharmacol. 2007; 49: 384-93.