Fexofenadine – an effective and safe drug in allergic rhinitis and urticaria Review article
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Published:
Sep 30, 2017
Keywords:
fexofenadine, allergic rhinitis, chronic urticaria
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Abstract
H1 blockers (LH) are the first-line treatment of AR and chronic urticaria. One of the most modern LH II generation is fexofenadine. Its mechanism of action is to bind to the H1 receptor and block the mast cell and inhibit its growth. Fexofenadine has no interaction: with other medicines, food and alcohol. Fexofenadine does not cause sedation and prolong QT interval and cardiovascular complications.
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Sybilski , A. J. (2017). Fexofenadine – an effective and safe drug in allergic rhinitis and urticaria. Medycyna Faktow (J EBM), 10(3(36), 267-269. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2137
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References
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2. Fitzsimons R., van der Poel L.A., Thornhill W. et al.: Antihistamine use in children. Arch. Dis. Child Educ. Pract. Ed. 2015; 100: 122-131.
3. Russell T., Stoltz M., Weir S.: Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers. Clin. Pharmacol. Ther. 1998; 64: 612-621.
4. Church M.K., Church D.S.: Pharmacology of antihistamines. Indian. J. Dermatol. 2013; 58: 219-224.
5. Akamine Y., Miura M., Komori H. et al.: The change of pharmacokinetics of fexofenadine enantiomers through the single and simultaneous grapefruit juice ingestion. Drug Metab. Pharmacokinet. 2015; 30: 352-357.
6. IMS: Sprzedaż ilościowa, 2016 r.
7. Akamine Y., Miura M., Komori H. et al.: Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Eur. J. Clin. Pharmacol. 2014; 70: 1087-1095.
8. Pratt C.M., Mason J., Russell T. et al.: Cardiovascular Safety of Fexofenadine HCl. Am. J. Cardiol. 1999; 83: 1451-1454.
9. Bernstein D.I., Schoenwetter W.F., Nathan R.A. et al.: Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis. Ann. Allergy Asthma Immunol. 1997; 79: 443-448.
10. Liu H., Zheng Q., Farley J.M.: Antimuscarinic actions of antihistamines on the heart. J. Biomed. Sci. 2006; 13: 395-401.