The role of group B vitamins and uridine monophosphate – nutrients in the treatment of neuropathic pain Review article
Article Sidebar
Main Article Content
Abstract
Neuropathic pain, which can commonly be called pain of the damaged nerve, is a symptom that appears in the course of numerous disease entities. A typical feature of neuropathic pain is poor response to standard pain killers. Treatment of diseases in which neuropathic pain occurs is long-term due to slow nerve regeneration. Moreover, in many cases full regeneration of the nervous system is impossible, which causes the pain to accompany the patient for the rest of his life.
Due to the ineffectiveness of typical analgesic treatment and chronicity of diseases with neuropathic pain, many doctors and patients use nutrients to support the regeneration process and improve the effectiveness of current treatment. Supplementation with vitamins and other nutrients should be taken into account in patients with neuropathic pain due to many years of experience in the use of this group of drugs and their good tolerance. In addition, one should remember about the adverse effect of vitamin deficiencies on the functions of the nervous system with a high prevalence of vitamin deficiencies in the elderly and people with selected disease entities, including alcoholism and digestive tract diseases.
Article Details
Copyright © by Medical Education. All rights reserved.
References
2. Haanpää M., Attal N., Backonja M.: NeuPSIG guidelines on neuropathic pain assessment. Pain 2011; 152: 14-27.
3. Finnerup N.B., Attal N., Haroutounian S. et al.: Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015; 14: 162-173.
4. Masuda R., Ajimi J., Murata T.: Pharmacotherapy for Neuropathic Pain in Japan. J. Nippon. Med. Sch. 2017; 84(6): 258-267.
5. Kim J.H., Hong J.T., Lee Ch.S. et al.: Prevalence of Neuropathic Pain and Patient-Reported Outcomes in Korean Adults with Chronic Low Back Pain Resulting from Neuropathic Low Back Pain. Asian Spine J. 2017; 11(6): 917-927.
6. Domżał T.M.: Bóle krzyża – rozpoznawanie i leczenie. Medycyna po Dyplomie 2011; 20(12): 34-45.
7. Rosenman S.D., Sacco M., Sharifi H.: Brachial plexus injury causation in newborns debated. OB/GYN 2010; 55(5): 42.
8. Bubko I., Gruber B.M., Anuszewska E.L.: The role of thiamine in neurodegenerative diseases. Postepy Hig. Med. Dosw. (Online) 2015; 69: 1096-1106. Review. Polish.
9. Zhang M., Han W., Hu S., Xu H.: Methylcobalamin: a potential vitamin of pain killer. Neural. Plast. 2013; 2013: 424651.
10. Manzardo A.M., He J., Poje A. et al.: Double-blind, randomized placebo-controlled clinical trial of benfotiamine for severe alcohol dependence. Drug Alcohol Depend. 2013; 133: 562-570.
11. Haupt E., Ledermann H., Köpcke W.: Benfotiamine in the treatment of diabetic polyneuropathy – a three-week randomized, controlled pilot study (BEDIP study). Int. J. Clin. Pharmacol. Ther. 2005; 43(2): 71-77.
12. Kretschmar C., Kaumeier S., Haase W.: Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation. Fortschr. Med. 1996; 114: 439-443.
13. Aufiero E., Stitik T.P., Foye P.M., Chen B.: Pyridoxine hydrochloride treatment of carpal tunnel syndrome: a review. Nutr. Rev. 2004; 62(3): 96-104.
14. Xu G., Lv Z.W., Feng Y. et al.: A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia. Pain Med. 2013; 14(6): 884-894.
15. Negrão L., Almeida P., Alcino S. et al.: Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag. 2014; 4(3): 191-196.
16. Negrão L., Nunes P.: Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies. Pain Manag. 2016; 6(1): 25-29.