Sinupret for treatment of rhinosinusitis Review article
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Published:
Sep 30, 2019
Keywords:
rhinosinusitis, children, adults, herbal remedies, efficacy, safety
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Abstract
In EPOS 2012 there are recommendations for use in rhinosinusitis products having secretolytic, immunomodulatory, anti-inflammatory, antiviral and antibacterial activities. Sinupret characterizes these properties. The article presents data from world literature confirming the efficacy and safety of Sinupret in acute and chronic inflammation of the paranasal sinuses in children and adults.
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Jurkiewicz , D., & Zielnik-Jurkiewicz , B. (2019). Sinupret for treatment of rhinosinusitis. Medycyna Faktow (J EBM), 12(3(44), 250-255. https://doi.org/10.24292/01.MF.0319.11
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References
1. Fokkens W.J., Lund V.J., Mullol J. et al.: EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50(1): 1-12.
2. Oliff H.S., Blumentahl M.: Proprietary Botanical Product, Scientific and Clinical Monograph for Sinupret. American Botanical Council [online: www. herbalgram.org].
3. Virgin F., Zhang S., Schuster D. et al.: The bioflavonoid compound, sinupret, stimulates transepithelial chloride transport in vitro and in vivo. Laryngoscope 2010; 120(5): 1051-1056.
4. Rossi A., Dehm F., Kiesselbach C.: The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo. Fitoterapia 2012; 83(4): 715-720.
5. Kreindler J.L., Chen B., Kreitman Y. et al.: The novel dry extract BNO 1011 stimulates chloride transport and ciliary beat frequency in human respiratory epithelial cultures. Am. J. Rhinol. Allergy 2012; 26(6): 439-443.
6. Glatthaar-Saalmüller B., Rauchhaus U., Rode S.: Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret® against viruses causing respiratory infections. Phytomed. 2011; 19(1): 1-7.
7. Werz O., Seifert S., Wosikowski K. et al.: Anti-viral and anti-inflammatory efficacies of Sinupret® dry extract BNO 1011 rationalize its therapeutic use in acute rhinosinusitis. Planta Med. 2013: 79-84.
8. Schmidt W.: Treatment of sinusitis in childhood. Fortschr. Med. 1975; 93(31): 1567-1569.
9. Tarasova G.D.: The administration of sinupret in the treatment of acute sinusitis in children. Vestn. Otorinolaringol. 2001; (2): 46-48.
10. Dzhaparidze S.V., Gegenava Kh.A., Dzhashi M.M. et al.: Estimation of effectiveness of peroral mucolytic agents in treatment of inflammatory diseases of middle ear and paranasal sinusitis. Georgian Med. News 2007; 145: 36-38.
11. Biebach K., Kramer A.: Effective treatment of rhinosinusitis in children. Praktische Pädiatrie 2004; 10: 333-336.
12. Popovic V.I., Koshel I.V.: Sinupret® as add-on therapy to saline irrigation for children with acute Post-Viral Rhinosinusitis. Clinical Phytoscience 2017; 3: 10-16.
13. Passali D., Loglisci M., Passali G.C. et al.: A prospective open-label study to assess the efficacy and safety of a herbal medicinal product (Sinupret) in patients with acute rhinosinusitis. ORL J. Otorhinolaryngol. Relat. Spec. 2015; 77(1): 27-32.
14. Jund R., Mondigler M., Steindl H. et al.; ARhiSi II study group: Clinical efficacy of a dry extract of five herbal drugs in acute viral rhinosinusitis. Rhinology 2012; 50(4): 417-426.
15. Jund R., Mondigler M., Steindl H. et al.: Clinical efficacy of a herbal drug combination in acute viral rhinosinusitis. MMW Fortschr. Med. 2015; 157: 6-11.
16. Jund R., Mondigler M., Stammer H. et al.: Herbal drug BNO 1016 is safe and effective in the treatment of acute viral rhinosinusitis. Acta Otolaryngol. 2015; 135(1): 42-50.
17. Melzer J., Saller R., Schapowal A. et al.: Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch. Komplementmed. 2006; 13(2): 78-87.
18. Bachert C., Mondigler M., Steindl H. et al.: Multicentre, randomised, double-blind, placebo-controlled, parallel-group dose-finding study of herbal medicine (dry extract) BNO 1016 in acute rhinosinusitis (ARhiSi-1). 84th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery 2013.
19. Neubauer N., März R.W.: Placebo-controlled, randomized double-blind clinical trial with Sinupret sugar-coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomed. 1994; 1: 177-181.
20. Braum D., März R.W.: Randomised, open comparative study of Sinupret versus N-acetylcysteine in cases of sinusitis. Neu-markt, Germany. Bionorica 1990.
21. Kraus P., Schwender W.: Randomized, open comparative study with Sinupret sugar-coated tablets vs. GeloMyrtol F. conducted at the Germany Army Hospital in Amberg. Paper presented at: 4th and international Congress on Phytotherapy 1992; Munich, Germany.
22. Peric A., Vezmar Kovacevic S., Gacesa D. et al.: Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray. ENT Updates 2017; 7(2): 68-74.
23. Ismail C.: Recent results on the rational for the Sinupret compound. HNO 2005; 53(1): S38-42.
24. Reden J., El-Hifnawi D., Zahnert T. et al.: The effect of a herbal combination of primrose, gentian root, vervain, elder flowers, and sorrel on olfactory function in patients with a sinonasal olfactory dysfunction. Rhinology 2011; 49(3): 342-346.
25. Melzer J., Saller R., Schapowa A. et al.: Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch Komplementmed 2006; 13: 78-87.
26. Richstein A., Mann W.: Treatment of chronic rhino-sinusitis with Sinupret. Schewiz. Zschr. GanzheitsMedizin 1999; 11: 280-283.
27. Palm J., Steiner I., Abramov-Sommariva D.: Assessment of efficacy and safety of the herbal medicinal product BNO 1016 in chronic rhinosinusitis. Rhinology 2017; 55(2): 142-151.
28. Koch A.K., Klose P., Lauche R.: A Systematic Review of Phytotherapy for Acute Rhinosinusitis. Forsch. Komplementmed. 2016; 23: 165-169.
2. Oliff H.S., Blumentahl M.: Proprietary Botanical Product, Scientific and Clinical Monograph for Sinupret. American Botanical Council [online: www. herbalgram.org].
3. Virgin F., Zhang S., Schuster D. et al.: The bioflavonoid compound, sinupret, stimulates transepithelial chloride transport in vitro and in vivo. Laryngoscope 2010; 120(5): 1051-1056.
4. Rossi A., Dehm F., Kiesselbach C.: The novel Sinupret® dry extract exhibits anti-inflammatory effectiveness in vivo. Fitoterapia 2012; 83(4): 715-720.
5. Kreindler J.L., Chen B., Kreitman Y. et al.: The novel dry extract BNO 1011 stimulates chloride transport and ciliary beat frequency in human respiratory epithelial cultures. Am. J. Rhinol. Allergy 2012; 26(6): 439-443.
6. Glatthaar-Saalmüller B., Rauchhaus U., Rode S.: Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret® against viruses causing respiratory infections. Phytomed. 2011; 19(1): 1-7.
7. Werz O., Seifert S., Wosikowski K. et al.: Anti-viral and anti-inflammatory efficacies of Sinupret® dry extract BNO 1011 rationalize its therapeutic use in acute rhinosinusitis. Planta Med. 2013: 79-84.
8. Schmidt W.: Treatment of sinusitis in childhood. Fortschr. Med. 1975; 93(31): 1567-1569.
9. Tarasova G.D.: The administration of sinupret in the treatment of acute sinusitis in children. Vestn. Otorinolaringol. 2001; (2): 46-48.
10. Dzhaparidze S.V., Gegenava Kh.A., Dzhashi M.M. et al.: Estimation of effectiveness of peroral mucolytic agents in treatment of inflammatory diseases of middle ear and paranasal sinusitis. Georgian Med. News 2007; 145: 36-38.
11. Biebach K., Kramer A.: Effective treatment of rhinosinusitis in children. Praktische Pädiatrie 2004; 10: 333-336.
12. Popovic V.I., Koshel I.V.: Sinupret® as add-on therapy to saline irrigation for children with acute Post-Viral Rhinosinusitis. Clinical Phytoscience 2017; 3: 10-16.
13. Passali D., Loglisci M., Passali G.C. et al.: A prospective open-label study to assess the efficacy and safety of a herbal medicinal product (Sinupret) in patients with acute rhinosinusitis. ORL J. Otorhinolaryngol. Relat. Spec. 2015; 77(1): 27-32.
14. Jund R., Mondigler M., Steindl H. et al.; ARhiSi II study group: Clinical efficacy of a dry extract of five herbal drugs in acute viral rhinosinusitis. Rhinology 2012; 50(4): 417-426.
15. Jund R., Mondigler M., Steindl H. et al.: Clinical efficacy of a herbal drug combination in acute viral rhinosinusitis. MMW Fortschr. Med. 2015; 157: 6-11.
16. Jund R., Mondigler M., Stammer H. et al.: Herbal drug BNO 1016 is safe and effective in the treatment of acute viral rhinosinusitis. Acta Otolaryngol. 2015; 135(1): 42-50.
17. Melzer J., Saller R., Schapowal A. et al.: Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch. Komplementmed. 2006; 13(2): 78-87.
18. Bachert C., Mondigler M., Steindl H. et al.: Multicentre, randomised, double-blind, placebo-controlled, parallel-group dose-finding study of herbal medicine (dry extract) BNO 1016 in acute rhinosinusitis (ARhiSi-1). 84th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery 2013.
19. Neubauer N., März R.W.: Placebo-controlled, randomized double-blind clinical trial with Sinupret sugar-coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomed. 1994; 1: 177-181.
20. Braum D., März R.W.: Randomised, open comparative study of Sinupret versus N-acetylcysteine in cases of sinusitis. Neu-markt, Germany. Bionorica 1990.
21. Kraus P., Schwender W.: Randomized, open comparative study with Sinupret sugar-coated tablets vs. GeloMyrtol F. conducted at the Germany Army Hospital in Amberg. Paper presented at: 4th and international Congress on Phytotherapy 1992; Munich, Germany.
22. Peric A., Vezmar Kovacevic S., Gacesa D. et al.: Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray. ENT Updates 2017; 7(2): 68-74.
23. Ismail C.: Recent results on the rational for the Sinupret compound. HNO 2005; 53(1): S38-42.
24. Reden J., El-Hifnawi D., Zahnert T. et al.: The effect of a herbal combination of primrose, gentian root, vervain, elder flowers, and sorrel on olfactory function in patients with a sinonasal olfactory dysfunction. Rhinology 2011; 49(3): 342-346.
25. Melzer J., Saller R., Schapowa A. et al.: Systematic review of clinical data with BNO-101 (Sinupret) in the treatment of sinusitis. Forsch Komplementmed 2006; 13: 78-87.
26. Richstein A., Mann W.: Treatment of chronic rhino-sinusitis with Sinupret. Schewiz. Zschr. GanzheitsMedizin 1999; 11: 280-283.
27. Palm J., Steiner I., Abramov-Sommariva D.: Assessment of efficacy and safety of the herbal medicinal product BNO 1016 in chronic rhinosinusitis. Rhinology 2017; 55(2): 142-151.
28. Koch A.K., Klose P., Lauche R.: A Systematic Review of Phytotherapy for Acute Rhinosinusitis. Forsch. Komplementmed. 2016; 23: 165-169.