Safety of rosuvastatin and ezetimibe combination therapy Review article

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Karolina Semczuk-Kaczmarek
Agnieszka Kapłon-Cieślicka

Abstract

The current European guidelines on the management of dyslipidemia have introduced significant changes compared to the recommendations from 2016 by reducing the low-density lipoprotein (LDL) cholesterol treatment targets. It is recommended that high- and very high-risk patients should achieve at least a 50% reduction from baseline LDL concentrations with a target of < 70 mg/dL and < 55 mg/dl, respectively. However, for many patients, even a strong statin in monotherapy is not sufficient to achieve the recommended LDL level. Combination therapy with a strong statin (e.g. rosuvastatin) and ezetimibe reduces LDL concentration by up to 65%. In addition, adding ezetimibe to statin therapy does not increase the risk of side effects. As demonstrated in the IMPROVE-IT trial, combination therapy with statin and ezetimibe is safe and well tolerated.

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How to Cite
Semczuk-Kaczmarek , K., & Kapłon-Cieślicka , A. (2020). Safety of rosuvastatin and ezetimibe combination therapy. Medycyna Faktow (J EBM), 13(2(47), 158-167. https://doi.org/10.24292/01.MF.0220.4
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