Small patient – big problem. Diagnostics and treatment of gastroesophageal reflux in infants and young children Review article
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Published:
Mar 31, 2021
Keywords:
gastroesophageal reflux, gastroesophageal reflux disease, infants, children, guidelines, proton pump inhibitors, omeprazole
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Abstract
Gastroesophageal reflux is the movement of gastric contents into the esophagus. Is one of the most common motility disorders in children. In newborns and infants predominant is physiological reflux caused by immaturity of digestive tract. Gastroesophageal reflux disease is reflux that causes complications and/or esophagitis. Article presents actual gastroesophageal reflux disease diagnostic and treatment recommendations according to the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines.
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How to Cite
Oracz , G. (2021). Small patient – big problem. Diagnostics and treatment of gastroesophageal reflux in infants and young children. Medycyna Faktow (J EBM), 14(1(50), 69-77. https://doi.org/10.24292/01.MF.0121.9
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References
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2. Gonzalez Ayerbe JI, Hauser B, Salvatore S et al. Diagnosis and Management of Gastroesophageal Reflux Disease in Infants and Children: from Guidelines to Clinical Practice. Pediatr Gastroenterol Hepatol Nutr. 2019; 22(2): 107-21.
3. Singendonk M, Goudswaard E, Langendam M et al. Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review. J Pediatr Gastroenterol Nutr. 2019; 68: 811-7.
4. Lopez RN, Lemberg DA. Gastro-oesophageal reflux disease in infancy: a review based on international guidelines. Med J Aust. 2020; 212(1): 40-4.
5. Zenzeri L, Quitadamo P, Tambucci R et al. Role of non-acid gastro-esophageal reflux in children with respiratory symptoms. Pediatr Pulmonol. 2017; 52(5): 669-74.
6. Jakubczyk M, Czerwionka-Szaflarska M, Jakubczyk P. Odległe skutki choroby refluksowej przełyku. Pediatr Współcz Gastroenterol Hepatol Żywienie Dziecka. 2006; 8(3): 155-8.
7. Lightdale JR, Gremse DA; Section on Gastroenterology, Hepatology and Nutrition. Gastroesophageal reflux: management guidance for the pediatrician. Pediatrics. 2013; 131(5): e1684-95.
8. Romano C, van Wynckel M, Hulst J et al. European Society for Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with neurological impairment. J Pediatr Gastroenterol Nutr. 2017; 65: 242-64.
9. Vandenplas Y, Rudolph CD, Di Lorenzo C et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009; 49(4): 498-547.
10. van der Pol RJ, Smits MJ, Venmans L et al. Diagnostic accuracy of tests in pediatric gastroesophageal reflux disease. J Pediatr. 2013; 162(5): 983-7. e1-4.
11. Szafarska-Popławska A, Mierzwa G, Bała G et al. Wartość pH-impedancji w diagnostyce refluksu żołądkowo-przełykowego. Gastroenterol Pol. 2007; 14: 251-5.
12. Lee ALH, Varjavandi V, Lemberg DA et al. Does Combined Multichannel Intraluminal Impedance and pH (MII-pH) Testing Improve Clinical Outcomes in Children With Gastroesophageal Reflux Disease? J Pediatr Gastroenterol Nutr. 2020; 71(5): 596-603.
13. Kierkus J, Oracz G, Korczowski B et al. Comparative safety and efficacy of proton pump inhibitors in pediatric gastroesophageal reflux disease. Drug Saf. 2014; 37: 309-16.
14. O’Reilly D, Conway R, O’Connor L et al. Use of anti-reflux medications in infants under 1 year of age: a retrospective drug utilization study using national prescription reimbursement data. Eur J Pediatr. 2020; 179(12): 1963-7.
15. Czerwionka-Szaflarska M, Mierzwa G, Kuczyńska R. Ocena skuteczności leczenia inhibitorem pompy protonowej choroby refluksowej przełyku u dzieci. Pol Merkuriusz Lek. 2004; 16(93): 217-9.
16. Bestebreurtje P, de Koning BAE, Roeleveld N et al. Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial. Eur J Drug Metab Pharmacokinet. 2020; 45(5): 635-43.
17. Dekonenko C, Holcomb GW. 3rd Laparoscopic Fundoplication for the Surgical Management of Gastroesophageal Reflux Disease in Children. Eur J Pediatr Surg. 2020; 30(2): 150-5.
2. Gonzalez Ayerbe JI, Hauser B, Salvatore S et al. Diagnosis and Management of Gastroesophageal Reflux Disease in Infants and Children: from Guidelines to Clinical Practice. Pediatr Gastroenterol Hepatol Nutr. 2019; 22(2): 107-21.
3. Singendonk M, Goudswaard E, Langendam M et al. Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review. J Pediatr Gastroenterol Nutr. 2019; 68: 811-7.
4. Lopez RN, Lemberg DA. Gastro-oesophageal reflux disease in infancy: a review based on international guidelines. Med J Aust. 2020; 212(1): 40-4.
5. Zenzeri L, Quitadamo P, Tambucci R et al. Role of non-acid gastro-esophageal reflux in children with respiratory symptoms. Pediatr Pulmonol. 2017; 52(5): 669-74.
6. Jakubczyk M, Czerwionka-Szaflarska M, Jakubczyk P. Odległe skutki choroby refluksowej przełyku. Pediatr Współcz Gastroenterol Hepatol Żywienie Dziecka. 2006; 8(3): 155-8.
7. Lightdale JR, Gremse DA; Section on Gastroenterology, Hepatology and Nutrition. Gastroesophageal reflux: management guidance for the pediatrician. Pediatrics. 2013; 131(5): e1684-95.
8. Romano C, van Wynckel M, Hulst J et al. European Society for Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with neurological impairment. J Pediatr Gastroenterol Nutr. 2017; 65: 242-64.
9. Vandenplas Y, Rudolph CD, Di Lorenzo C et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009; 49(4): 498-547.
10. van der Pol RJ, Smits MJ, Venmans L et al. Diagnostic accuracy of tests in pediatric gastroesophageal reflux disease. J Pediatr. 2013; 162(5): 983-7. e1-4.
11. Szafarska-Popławska A, Mierzwa G, Bała G et al. Wartość pH-impedancji w diagnostyce refluksu żołądkowo-przełykowego. Gastroenterol Pol. 2007; 14: 251-5.
12. Lee ALH, Varjavandi V, Lemberg DA et al. Does Combined Multichannel Intraluminal Impedance and pH (MII-pH) Testing Improve Clinical Outcomes in Children With Gastroesophageal Reflux Disease? J Pediatr Gastroenterol Nutr. 2020; 71(5): 596-603.
13. Kierkus J, Oracz G, Korczowski B et al. Comparative safety and efficacy of proton pump inhibitors in pediatric gastroesophageal reflux disease. Drug Saf. 2014; 37: 309-16.
14. O’Reilly D, Conway R, O’Connor L et al. Use of anti-reflux medications in infants under 1 year of age: a retrospective drug utilization study using national prescription reimbursement data. Eur J Pediatr. 2020; 179(12): 1963-7.
15. Czerwionka-Szaflarska M, Mierzwa G, Kuczyńska R. Ocena skuteczności leczenia inhibitorem pompy protonowej choroby refluksowej przełyku u dzieci. Pol Merkuriusz Lek. 2004; 16(93): 217-9.
16. Bestebreurtje P, de Koning BAE, Roeleveld N et al. Rectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial. Eur J Drug Metab Pharmacokinet. 2020; 45(5): 635-43.
17. Dekonenko C, Holcomb GW. 3rd Laparoscopic Fundoplication for the Surgical Management of Gastroesophageal Reflux Disease in Children. Eur J Pediatr Surg. 2020; 30(2): 150-5.