Inflammatory pain of the locomotor system Review article

Abstract

Tissue damage is a result of an injury or disease process, and releases a cascade of mediators leading to the inflammation, sensitization processes in the nervous system, this consequently lead to the formation of an inflammatory pain component. Inflammatory pain is a consequence of the body’s defensive response. The inflammatory pain component is present in both acute and chronic pain syndromes. Most often, inflammatory pain affects the musculoskeletal system and is associated with osteoarthritis or takes the form of pains in the lower spine. Characteric for the inflammatory pain in the locomotor system is no improvement after rest (this differs from somatic overload, mechanical pain) and intensification at night, especially in its second part. Due to the complex pathomechanism of inflammatory pain, its treatment must be multimodal, and properly selected, contextual pharmacotherapy is one of the key elements of treatment.