Wpływ czynników ryzyka związanych ze stylem życia na rozwój nowotworu piersi Artykuł przeglądowy
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Abstrakt
Rak piersi jest najczęściej wynikiem wzajemnych korelacji pomiędzy determinantami hormonalnymi, środowiskowymi oraz genetycznymi. Mechanizmy jego rozwoju obejmują m.in.: wysokie stężenie estrogenu, upośledzenie metabolizmu glukozy, hiperglikemię, hiperinsulinemię, wysokie stężenie insulinopodobnego czynnika wzrostu 1, utrzymujący się stan zapalny i stres oksydacyjny oraz upośledzoną apoptozę komórkową. Celem pracy była analiza danych dotyczących czynników ryzyka raka piersi, które zostały podzielone zgodnie z okresem diagnozy na premenopauzalne i postmenopauzalne. W związku z tym, iż duża część determinant wystąpienia tego nowotworu ma charakter modyfikowalny, niezbędne jest zwiększanie świadomości populacji na jego temat. Zachowanie należnej masy ciała poprzez stosowanie zbilansowanej diety obfitującej w wapń, warzywa nieskrobiowe i produkty bogate w karotenoidy, przy jednoczesnych ograniczeniu spożycia alkoholu oraz dbałości o aktywność fizyczną, stanowi bowiem najlepszą prewencję raka piersi. Równocześnie konieczne jest prowadzenie dalszych badań mających na celu ostateczne wyjaśnienie niejednoznaczności aktualnych obserwacji.
Pobrania
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