Cardiovascular complications of selected antibodies used in oncological immunotherapy Review article

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Published: Apr 2, 2017
DOI: https://doi.org/10.24292/01.OR.300617.4
Keywords:
immunotherapy, monoclonal antibodies, transzumab, bevacizumab, pertuzumab, trastuzumab-emtansine, vascular endothelial growth factor

Main Article Content

Joanna Kufel-Grabowska
Greater Poland Centre of Oncology in Poznań

Abstract

Immunotherapy supports other therapeutic methods and is an important element in the fight against cancer. Its main tasks include stimulation and guidance of the immune system to fight cancer, inhibition of the mechanisms that block the immune system, and direct destruction of neoplastic cells. Different from chemotherapy or hormonal therapy, its mechanism of action is associated with a different profile of adverse events. HER2 receptor inhibitors may cause symptoms of heart failure, which usually recede, once the treatment has been discontinued. Bevacizumab, an anti-VEGF antibody, induces numerous cardiovascular complications, including arterial hypertension, arterial embolism, haemorrhage and haemoptysis as well as venous thromboembolism.

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How to Cite
1.
Kufel-Grabowska J. Cardiovascular complications of selected antibodies used in oncological immunotherapy. OncoReview [Internet]. 2017Apr.2 [cited 2024Nov.23];7(2(26):78-2. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/446
Issue
Vol 7 No 2(26) (2017)
Section
CARDIO-ONCOLOGY
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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