Hematopoietic stem cells transplantation in patients with multiple sclerosis – new hope or a dead end? Review article
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Published:
Dec 31, 2015
Keywords:
multiple sclerosis, hematopoietic cells, autograft
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Abstract
Multiple sclerosis is a chronic, inflammatory, incurable, neurological disease that leads to disability of the patient. There is no known cure for MS nowadays, but new treatments are still being tested. Due to MS is an autoimmune disorder, transplantologists decided to undergo procedure known as Hematopoietic Stem Cell Transplantation (HSCT) on patients with multiple sclerosis. Since 1997 scientists have carried clinical trials connected with HSCT and now results are satisfactory.
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References
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2. Burt R.K., Loh Y., Cohen B. et al.: Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurol. 2009; 8: 244-253.
3. Pérez-Miralles F., Sastre-Garriga J., Tintoré M. et al.: Clinical impact of early brain atrophy in clinically isolated syndromes. Mult. Scler. 2013; 19(14): 1878-1886.
4. Burt R.K., Burns W.H., Miller S.D.: Bone marrow transplantation for multiple sclerosis: returning to Pandora’s box. Immunol. Today 1997; 18(12): 559-561.
5. Fassas A., Anagnostopoulos A., Kasis A. et al.: Autologous stem cell transplantation in progressive multiple sclerosis – an interim analysis of efficacy. J. Clin. Immunol. 2000; 20(1): 24-30.
6. Mandalfino P., Rice G., Smith A. et al.: Bone marrow transplantation in multiple sclerosis. J. Neurol. 2000; 247(9): 691-695.
7. de Paula A., Sousa A., Malmegrim K.C. et al.: Autologous haematopoietic stem cell transplantation reduces abnormalities in the expression of immune genes in multiple sclerosis. Clin. Sci. (Lond.) 2015; 128(2): 111-120.
8. Nash R.A., Hutton G.J., Racke M.K. et al.: High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for relapsing-remitting multiple sclerosis (HALT-MS): a 3-year interim report. JAMA Neurol. 2015; 72(2): 159-169.
9. Shevchenko J.L., Kuznetsov A.N., Ionova T.I. et al.: Long-term outcomes of autologous hematopoietic stem cell transplantation with reduced-intensity conditioning in multiple sclerosis: physician’s and patient’s perspectives. Ann. Hematol. 2015; 94(7): 1149-1157.
10. Muraro P.A., Pasquini M., Atkins H.: Long term outcomes after autologous hematopoietic stem cell transplantation for treatment of MS. ECTRIMS Online Library 2015, Oct 9; 116682.
11. Kyrcz-Krzemień S., Helbig G., Torba K. et al.: Safety and efficacy of hematopoietic stem cells mobilization in patients with multiple sclerosis. Haematology 2015 [online: doi: 10.1179/1607845415Y.0000000049].
12. Mancardi G.L., Sormani M.P., Gualandi F. et al.: Autologous hematopoietic stem cell transplantation in multiple sclerosis: a phase II trial. Neurology 2015; 84: 981-988.
13. Mancardi G.: Further data on autologous haemopoietic stem cell transplantation in multiple sclerosis. Lancet Neurol. Published Online January 30, 2009 [doi: 10.1016/S1474-4422(09)70018-3].
14. Paz Soldán M.M., Weinshenker B.G.: Moving targets for hematopoietic stem cell transplantation for multiple sclerosis. JAMA Neurol. 2015; 72(2): 147-149.
15. Fassas A., Kimiskidis V.K., Sakellari I. et al.: Long-term results of stem cell transplantation for MS: a single-center experience. Neurology 2011; 76(12): 1066-1070.