In the quest for sources – role of gut flora in health and disease. Part I Review article
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Published:
Sep 30, 2015
Keywords:
fecal microbiota transplantation, gut microbiome, gut colonization
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Abstract
There is growing evidence for impact of gut flora on ethiology of multiple sclerosis and other autoimmune disorders. The current article summarizes the ongoing concepts of the role of physiological gut flora in human body, and especially its impact on immune system and protection against gut colonization by pathogenic bacteria.
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References
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2. Jandhyala S.M., Talukdar R., Subramanyam C. et al.: Role of the normal gut microbiota. World Journal of Gastroenterology 2015; 21(29): 8787-8803.
3. Ji B., Nielsen J.: From next-generation sequencing to systematic modeling of the gut microbiome. Frontiers in Genetics 2015; 6: 219.
4. Rosenbaum M., Knight R., Leibel R.L.: The gut microbiota in human energy homeostasis and obesity. Trends in endocrinology and metabolism. TEM 2015 [in press, doi: 10.1016/j.tem.2015.07.002].
5. Peterson L.W., Artis D.: Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nature reviews. Immunology 2014; 14(3): 141-53.
6. Brown E.M., Sadarangani M., Finlay B.B.: The role of the immune system in governing host-microbe interactions in the intestine. Nature Immunology 2013; 14(7): 660-667.
7. Thijm H.A., van der Waaij D.: The effect of three frequently applied antibiotics on the colonization resistance of the digestive tract of mice. The Journal of Hygiene 1979; 82(3): 397-405.
8. Taur Y., Xavier J.B., Lipuma L. et al.: Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 2012; 55(7): 905-914.
9. Biliński J., Marchel H., Rusicka P. et al.: Assessment of bacterial gut colonization prior to allogeneic stem cell transplantation as a tool for prediction of systemic infections during early postHSCT period. Bone Marrow Transplant. 2014; 49(S): 101.
10. Ubeda C., Bucci V., Caballero S. et al.: Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization. Infection and Immunity 2013; 81(3): 965-973.
11. van Nood E., Vrieze A., Nieuwdorp M. et al.: Duodenal infusion of donor feces for recurrent Clostridium difficile. The New England Journal of Medicine 2013; 368(5): 407-415.