Treatment of knee osteoarthritis with acemetacin Case report
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Published:
Dec 31, 2022
Keywords:
non-steroidal anti-inflammatory drugs, osteoarthritis, knee joint, acemetacin, cardiovascular safety
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Abstract
The principle therapeutics in osteoarthritis treatment are non-steroidal anti-inflammatory drugs. The guidelines do not indicate any preparation as the preferred in initiation of the treatment. The anti-inflammatory drug should be selected individually, depending on the patient’s age, comorbidities and contraindications to the use of particular drug. In patients with cardiac risk factors, it is necessary to ensure cardiovascular safety by appropriate selection of an anti-inflammatory drug and/or modification of cardiac pharmacotherapy.
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How to Cite
Walewska, E., & Rell, K. (2022). Treatment of knee osteoarthritis with acemetacin. Medycyna Faktow (J EBM), 15(4(57), 432-434. https://doi.org/10.24292/01.MF.0422.10
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References
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2. Overton C, Nelson AE, Neogi T. Osteoarthritis Treatment Guidelines from Six Professional Societies: Similarities and Differences. Rheum Dis Clin North Am. 2022; 48(3): 637-57.
3. Zhang W, Doherty M, Peat G et al. EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2010; 69(3): 483-9.
4. Osthoff A-KR, Niedermann K, Braun J et al. 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 2018; 77(9): 1251-60.
5. Ribeiro H, Rodrigues I, Napoleão L et al. Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features. Biomed Pharmacother. 2022; 150: 112958.
6. Chou C, Tsai Y. A double-blind, randomized, controlled parallel group study evaluating the efficacy and safety of acemetacin for the management of osteoarthritis. Int J Clin Pharmacol Res. 2002; 22(1): 1-6.
7. Leeb B, Bucsi L, Keszthelyi B et al. Behandlung der gonarthrose. Der Orthopäde. 2004; 33(9): 1032-41.
8. Antman EM, Bennett JS, Daugherty A et al.; American Heart Association. Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation. 2007; 115: 1634-42.
9. Gallacchi G, Hodinka L. [Randomized, double blind, multicentre, parallel group study to compare efficacy and safety of acemetacin and indometacin in patients with activated osteoarthrosis of the knee]. Praxis (Bern 1994). 2009; 98: 635-42.
10. Masclee GMC, Straatman H, Arfè A et al. Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project. PLoS ONE. 2018, 13(11): e0204746.