The place of naproxen in the pharmacotherapy of pain and fever. What do we know in 2022? Review article
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Published:
Dec 31, 2022
Keywords:
pain, fever, naproxen, non-steroidal anti-inflammatory drugs, sodium salt
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Abstract
An increase body temperature above 38°C should be treated as an undesirable condition and efforts should be made to lower it to a safe level. The most commonly used drugs for this purpose are non-steroidal anti-inflammatory drugs which inhibit the synthesis of prostaglandins mediating the development of inflammation. However, this group of drugs is not uniform in terms of antipyretic effect. One of the most commonly used substances from this group is naproxen, which is distinguished by favourable pharmacokinetics. It is rapidly absorbed from the gastrointestinal tract and has a peripheral half-life of 12–15 hours, which guarantees a stable antipyretic effect.
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Woroń , J. (2022). The place of naproxen in the pharmacotherapy of pain and fever. What do we know in 2022?. Medycyna Faktow (J EBM), 15(4(57), 401-403. https://doi.org/10.24292/01.MF.0422.4
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3. Malec-Milewska M, Woroń J (ed). Kompendium leczenia bólu. Medical Education, Warszawa 2017.
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5. Gschwend MH, Erenmemişoglu A, Martin W et al. Pharmacokinetic and bioequivalence study of meloxicam tablets in healthy male subjects. Arzneimittelforschung. 2007; 57(5): 264-8.