Amlodypine – the ideal antihypertensive agent in the combination theraphy Review article

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Danuta Czarnecka
Agnieszka Bednarek

Abstract

Hypertension has been recognized as an important risk factor for cardiovascular disease and a leading factor for mortality. In the majority of patients it is necessary to use of more than one agent to achieve target blood pressure. Combination treatment for hypertension as initial therapy can reduce blood pressure to a greater extent and more rapidly. Given the vast array of available antihypertensive agents, the number of potential combinations is large; however, rational choice must be based on the characteristics of each agent and their complementary mechanisms of action. Amlodipine, calcium antagonist, has favourable pharmacokinetic and pharmacodynamics profile, and this agent was widely used with other antihypertensives in clinical trials. Therefore, we presented the main characteristic of amlodipine and preferred drug combination containing amlodipine.

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Czarnecka, D., & Bednarek, A. (2012). Amlodypine – the ideal antihypertensive agent in the combination theraphy. Medycyna Faktow (J EBM), 5(1(14), 43-48. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2492
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