ADVANCE and ADVANCE-ON studies – benefits from perindopril and indapamide therapy in patients with diabetes Review article

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Piotr Jędrusik
Jacek Lewandowski

Abstract

In the ADVANCE study, benefits from fixed-dose combination therapy with perindopril and indapamide were shown in patients with diabetes type 2 regardless of baseline blood pressure values, the diagnosis of hypertension, and concomitant use of other antihypertensive drugs. During more than 4 years of follow-up, active therapy resulted in a reduction of the combined rate of macrovascular and microvascular complications of diabetes, cardiovascular mortality, and total mortality. The ADVANCE-ON study was a post-trial 6-year follow-up of ADVANCE study participants. A beneficial effect on total mortality and cardiovascular mortality was found to persist in the patients previously assigned to perindopril and indapamide therapy despite no differences in blood pressure and other risk factors between the two study groups after termination of the randomized trial.

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How to Cite
Jędrusik , P., & Lewandowski , J. (2015). ADVANCE and ADVANCE-ON studies – benefits from perindopril and indapamide therapy in patients with diabetes. Medycyna Faktow (J EBM), 8(1(26), 71-76. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2327
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References

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