Bacterial lysate (OM-85 BV) and serum concentrations of hBD-1 and immunoglobulin in children with asthma and recurrent respiratory infections Commentary

Abstract

Recurrent acute tonsillitis is a very common disorder among younger school-age children and teenagers. It is generally defined as 3 episodes of tonsillitis in the preceding year, 5 episodes in the preceding 2 years or 7 episodes in the preceding 3 years. Renal, joints or cardiac complications may occur as a result of recurrent tonsils inflammation. Moreover, tonsils no longer fulfill its defensive function in the organism. Recurrent acute tonsillitis may be treated surgically by removing the tonsils (tonsillectomy) or pharmacologically using antibiotics and immunomodulators. The best-studied and most widely used of immunomodulators is a bacterial lysate in the form of an oral multivalent vaccine OM-85. The bacterial lysate used in children with recurrent acute tonsillitis causes a significant decrease in the incidence of acute episodes and reduces the amount of tonsillectomies.