Current controversies in perinatology – progesterone treatment in pregnancy Review article
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Published:
Dec 31, 2016
Keywords:
cervical shortening, premature labor, progesterone therapy
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Abstract
Preterm birth is still one of the most important problems in maternal-child health. There is increasing evidence that progesterone supplementation can reduce the rate of spontaneous preterm birth in low and high risk pregnant women. Recommendations for the use of progesterone supplementation to prevent premature birth are given by most of scientific associations of specialists conducting scientific research on the field of perinatology.
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Tomaszewski, J. (2016). Current controversies in perinatology – progesterone treatment in pregnancy. Medycyna Faktow (J EBM), 9(4(33), 315-319. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2205
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References
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2. Norwitz E.R., Caughey A.B.: Progesterone supplementation and the prevention of preterm birth. Rev. Obstet. Gynecol. 2011; 4: 60-72.
3. da Fonseca E.B., Bittar R.E., Carvalho M.H. et al.: Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneus preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. AJOG 2003; 188: 419-424.
4. Norman J.E., Marlow N., Messow C.M. et al.; OPPTIMUM study group: Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 2016; 387(10033): 2106-2116.
5. Romero R., Nicolaides K.H., Conde-Agudelo A. et al.: Vaginal progesterone decreases preterm birth ≤ 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study. Ultrasound Obstet. Gynecol. 2016; 48(3): 308-317.
6. van Os M.A., van der Ven A.J., Kleinrouweler C.E. et al.: Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial. Am. J. Perinatol. 2015; 32(10): 993-1000.
7. McNamara H.C., Wood R., Chalmers J. et al.; STOPPIT Baby Follow-up Study: The effect of prophylactic progesterone in twin pregnancy on childhood outcome. PLoS One. 2015; 10(4): e0122341.
8. Schuit E., Stock S., Rode L. et al; Global Obstetrics Network (GONet) collaboration: Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis. BJOG 2015; 122(1): 27-37.
9. O’Brien J.M.: Medication safety is still an issue in obstetrics 50 years after the Kefauver-Harris amendments: the case of progestogens. Ultrasound. Obstet. Gynecol. 2013; 42: 247-253.
2. Norwitz E.R., Caughey A.B.: Progesterone supplementation and the prevention of preterm birth. Rev. Obstet. Gynecol. 2011; 4: 60-72.
3. da Fonseca E.B., Bittar R.E., Carvalho M.H. et al.: Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneus preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. AJOG 2003; 188: 419-424.
4. Norman J.E., Marlow N., Messow C.M. et al.; OPPTIMUM study group: Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet 2016; 387(10033): 2106-2116.
5. Romero R., Nicolaides K.H., Conde-Agudelo A. et al.: Vaginal progesterone decreases preterm birth ≤ 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study. Ultrasound Obstet. Gynecol. 2016; 48(3): 308-317.
6. van Os M.A., van der Ven A.J., Kleinrouweler C.E. et al.: Preventing Preterm Birth with Progesterone in Women with a Short Cervical Length from a Low-Risk Population: A Multicenter Double-Blind Placebo-Controlled Randomized Trial. Am. J. Perinatol. 2015; 32(10): 993-1000.
7. McNamara H.C., Wood R., Chalmers J. et al.; STOPPIT Baby Follow-up Study: The effect of prophylactic progesterone in twin pregnancy on childhood outcome. PLoS One. 2015; 10(4): e0122341.
8. Schuit E., Stock S., Rode L. et al; Global Obstetrics Network (GONet) collaboration: Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis. BJOG 2015; 122(1): 27-37.
9. O’Brien J.M.: Medication safety is still an issue in obstetrics 50 years after the Kefauver-Harris amendments: the case of progestogens. Ultrasound. Obstet. Gynecol. 2013; 42: 247-253.