A combination of acetaminophen and ibuprofen in treating fever in children Commentary to: Ian M. Paul, Philip D. Walson. Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review
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Published:
Sep 30, 2022
Keywords:
acetaminophen, ibuprofen, fever, children, meta-analysis
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Abstract
Acetaminophen and ibuprofen are often used in treating fever in children. Their mechanisms of action are different: ibuprofen is a non-selective COX inhibitor, while acetaminophen probably works by inhibiting COX, but it also affects the descending core serotonergic pathways. Both drugs can be used simultaneously: or in the combined preparation or alternately. The effectiveness of both regimens was tested by Paul and Walson. This paper discusses the results of their meta-analysis.
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How to Cite
Rutkowska-Sak, L. (2022). A combination of acetaminophen and ibuprofen in treating fever in children. Medycyna Faktow (J EBM), 15(3(56), 303-306. https://doi.org/10.24292/01.MF.0322.5
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References
1. Paul IM, Walson PD. Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review. Curr Med Res Opin. 2021; 37(8): 1363-75.
2. Hryniewicz W, Albrecht P, Radzikowski A et al. Rekomendacje postępowania w pozaszpitalnych zakażeniach układu oddechowego – Narodowy Program Ochrony Antybiotyków Ministerstwa Zdrowia. Narodowy Instytut Leków, Warszawa 2016: 183-210.
3. Doniec Z, Jackowska T, Sybilski A et al. Rekomendacje postępowania w praktyce lekarza POZ – KOMPAS GORĄCZKA. Fam Med Prim Care Rev. 2021; 23(1): 14.
4. Vyas FI, Rana DA, Patel PM, et al. Randomized comparative trial of efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children. Perspect Clin Res. 2014; 5(1): 25-31.
5. Paul IM, Sturgis SA, Yang C, et al. Efficacy of standard doses of ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. Clin Ther. 2010; 32(14): 2433-40.
6. Hay AD, Costelloe C, Redmond NM et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomized controlled trial. BMJ. 2008; 337(2): a1302.
7. Lal A, Gomber S, Talukdar B. Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol. Indian J Pediatr. 2000; 67(12): 865-70.
2. Hryniewicz W, Albrecht P, Radzikowski A et al. Rekomendacje postępowania w pozaszpitalnych zakażeniach układu oddechowego – Narodowy Program Ochrony Antybiotyków Ministerstwa Zdrowia. Narodowy Instytut Leków, Warszawa 2016: 183-210.
3. Doniec Z, Jackowska T, Sybilski A et al. Rekomendacje postępowania w praktyce lekarza POZ – KOMPAS GORĄCZKA. Fam Med Prim Care Rev. 2021; 23(1): 14.
4. Vyas FI, Rana DA, Patel PM, et al. Randomized comparative trial of efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children. Perspect Clin Res. 2014; 5(1): 25-31.
5. Paul IM, Sturgis SA, Yang C, et al. Efficacy of standard doses of ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. Clin Ther. 2010; 32(14): 2433-40.
6. Hay AD, Costelloe C, Redmond NM et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomized controlled trial. BMJ. 2008; 337(2): a1302.
7. Lal A, Gomber S, Talukdar B. Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol. Indian J Pediatr. 2000; 67(12): 865-70.