Patients’ profiles in whom it is worth to use oral oral immunization with bacterial extract to prevent respiratory infections Review article
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Published:
Sep 30, 2017
Keywords:
OM-85, prevention, respiratory infections
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Abstract
Infections of the upper and lower respiratory tract are still an important medical and economic problem. Nowadays we are experiencing significant difficulties in treating infections, mainly due to the growing problem of antibiotic resistance. It is believed that antibiotic resistance is the epidemic of the 21st century. Oral immunomodulatory drugs of bacterial origin have been used for many years in clinical practice. The paper presents the publications, including the results of previous research and current research. The current situation justifies the prospect of improving the immune system in patients with recurrent respiratory infections.
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Jahnz-Różyk, K., & Zarzycka, J. (2017). Patients’ profiles in whom it is worth to use oral oral immunization with bacterial extract to prevent respiratory infections. Medycyna Faktow (J EBM), 10(3(36), 289-292. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/2141
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References
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8. Schaad U.B., Mütterlein R., Goffin H.: Immunostimulation with OM-85 in children with recurrent infections of the upper respiratory tract. A double blind, placebo-controlled multicenter study. Chest 2002; 122: 2042-2049.
9. Genel F., Kutukculer N.: Prospective, randomized comparison of OM-85 BV and a prophylactic antibiotic in children with recurrent infections and immunoglobulin A and/or G subclass deficiency. Curr. Ther. Res. Clin. Exp. 2003; 64: 600-615.
10. Razi CH., Harmancik B., Abaci A. et al.: The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J. Allerg. Clin. Immunol. 2010; 126: 763-769.
11. Ahrens J.A.: Double blind multicentre trial with Broncho-Vaxom in adults. Atemwegs-Lungenkrankheiten 1983; 9: 424-427.
12. Heintz B., Schlenter W.W., Kirsten R., Nelson K.: Clinical efficacy of Broncho-Vaxom in adult patients with chronic purulent sinusitis: a multicentric, placebo-controlled, double-blind study. Int. J. Clin. Pharmacol. Ther. Toxicol. 1989; 27: 530-534.
13. Laboratoires OM. Broncho-Vaxom in the Treatment and Prevention of Chronic Bronchitis: A Multicentre Study in 1218 Patients, Published by the Scientific Department, Laboratoires OM, Geneva 1982.
14. Cvoriscec B., Ustar M., Pardon R. et al.: Oral immunotherapy of chronic bronchitis: a double-blind placebo controlled multicentre study. Respiration 1989; 55: 129-135.
15. Orcel B., Delclaux B., Baud M., Derenne J.P.: Oral immunization with bacterial extracts for protection against acute bronchitis in elderly institutionalized patients with chronic bronchitis. Eur. Respir. J. 1994; 7: 446-452.
16. Collet J.P., Shapiro S., Ernst P. et al.: Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease. The PARI-IS Study Steering Committee and Research Group. Prevention of Acute Respiratory Infection by an Immunostimulant. Am. J. Respir. Crit. Care Med. 1997; 156: 1719-1724.
17. Li J., Zhenh J.P., Yuan J.P. et al.: Protective effect of a bacterial extract against acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease. Chin. Med. J. 2004; 117: 828-834.
18. Soler M., Mütterlein R., Cozma G.: Prevention of Exacerbations in Chronic Bronchitis and COPD with OM-85, American Thoracic Society Congress, Orlando, 21–26 May 2004.
19. Capetti A., Cossu M.W., Carenzi L., Rizzardini G.: Four years of immunization with OM-85 BV to prevent respiratory infections in HIV+ patients. Hum. Vaccin. Immunother. 2013; 9(9): 1849-1851.
20. Pan L., Jiang X.G., Guo J. et al.: Effects of OM-85 BV in patients with chronic obstructive pulmonary disease: A systematic review and meta- analysis. J. Clin. Pharmacol. 2015; 55(10): 1086-1092.
21. Goldcopd.org.
2. Ahrens J.: Multicentre double-blind clinical trial with Broncho-Vaxom in children. Therapiewoche 1984; 34: 3469-3475.
3. Zagar S., Löfler-Badzek D.: Broncho-Vaxom® in children with rhinosinusitis: a double-blind clinical trial. ORL 1998; 50: 397-404.
4. Paupe J.: Immunotherapy with an oral bacterial extract (OM-85 BV) for upper respiratory infections. Respiration 1991; 58: 150-154.
5. Collet J.P., Ducruet T., Kramer M.S. et al.: Stimulation of nonspecific immunity to reduce the risk of recurrent infections in children attending day-care centers. The Epicrèche Research Group. Pediatr Infect Dis J 1993; 12(8): 648-652.
6. Jara-Perez J.V., Berber A.: Primary prevention of acute respiratory tract infections in children using a bacterial immunostimulant: a double- masked, placebo-controlled clinical trial. Clinical Therapeutics 2001; 22: 748-759.
7. Gutierrez-Tarango M.D., Berber A.: Safety and efficacy of two courses of OM-85 BV in the prevention of respiratory tract infections in children during 12 months. Chest 2001; 119: 1742-1748.
8. Schaad U.B., Mütterlein R., Goffin H.: Immunostimulation with OM-85 in children with recurrent infections of the upper respiratory tract. A double blind, placebo-controlled multicenter study. Chest 2002; 122: 2042-2049.
9. Genel F., Kutukculer N.: Prospective, randomized comparison of OM-85 BV and a prophylactic antibiotic in children with recurrent infections and immunoglobulin A and/or G subclass deficiency. Curr. Ther. Res. Clin. Exp. 2003; 64: 600-615.
10. Razi CH., Harmancik B., Abaci A. et al.: The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J. Allerg. Clin. Immunol. 2010; 126: 763-769.
11. Ahrens J.A.: Double blind multicentre trial with Broncho-Vaxom in adults. Atemwegs-Lungenkrankheiten 1983; 9: 424-427.
12. Heintz B., Schlenter W.W., Kirsten R., Nelson K.: Clinical efficacy of Broncho-Vaxom in adult patients with chronic purulent sinusitis: a multicentric, placebo-controlled, double-blind study. Int. J. Clin. Pharmacol. Ther. Toxicol. 1989; 27: 530-534.
13. Laboratoires OM. Broncho-Vaxom in the Treatment and Prevention of Chronic Bronchitis: A Multicentre Study in 1218 Patients, Published by the Scientific Department, Laboratoires OM, Geneva 1982.
14. Cvoriscec B., Ustar M., Pardon R. et al.: Oral immunotherapy of chronic bronchitis: a double-blind placebo controlled multicentre study. Respiration 1989; 55: 129-135.
15. Orcel B., Delclaux B., Baud M., Derenne J.P.: Oral immunization with bacterial extracts for protection against acute bronchitis in elderly institutionalized patients with chronic bronchitis. Eur. Respir. J. 1994; 7: 446-452.
16. Collet J.P., Shapiro S., Ernst P. et al.: Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease. The PARI-IS Study Steering Committee and Research Group. Prevention of Acute Respiratory Infection by an Immunostimulant. Am. J. Respir. Crit. Care Med. 1997; 156: 1719-1724.
17. Li J., Zhenh J.P., Yuan J.P. et al.: Protective effect of a bacterial extract against acute exacerbation in patients with chronic bronchitis accompanied by chronic obstructive pulmonary disease. Chin. Med. J. 2004; 117: 828-834.
18. Soler M., Mütterlein R., Cozma G.: Prevention of Exacerbations in Chronic Bronchitis and COPD with OM-85, American Thoracic Society Congress, Orlando, 21–26 May 2004.
19. Capetti A., Cossu M.W., Carenzi L., Rizzardini G.: Four years of immunization with OM-85 BV to prevent respiratory infections in HIV+ patients. Hum. Vaccin. Immunother. 2013; 9(9): 1849-1851.
20. Pan L., Jiang X.G., Guo J. et al.: Effects of OM-85 BV in patients with chronic obstructive pulmonary disease: A systematic review and meta- analysis. J. Clin. Pharmacol. 2015; 55(10): 1086-1092.
21. Goldcopd.org.