Valsartan – a good choice Commentary
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Published:
Dec 31, 2017
Keywords:
valsartan, cardiovascular disease, heart failure
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Abstract
Valsartan is present on the market since almost 30 years and is one of the most researched molecules belonging to angiotensin II receptor blockers (ARB). There are many data coming from randomized trials about high efficiency and safety in patients with hypertension, atherosclerosis or heart failure. In light of most recent research, valsartan combine with neprilysin inhibitor reduce cardiac mortality by 20% compare to standard treatment strategy with angiotensin I converting enzyme inhibitors (ACE-I) in patients with heart failure.
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Kręcki, R. (2017). Valsartan – a good choice. Medycyna Faktow (J EBM), 10(4(37), 344-347. https://doi.org/10.24292/01.MF.0417.7
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References
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4. Kjeldsen S.E., Julius S., Mancia G. et al.: Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial. J. Hypertens. 2006; 24: 1405-1412.
5. Pfeffer M.A., McMurray J.J.V., Velazquez E.J. et al.: Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N. Engl. J. Med. 2003; 349: 1893-1906.
6. Mistry N.B., Westheim A.S., Kjeldsen S.E.: The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials. Expert Opin. Pharmacother. 2006; 7: 575-581.
7. Weber M.A.: Comparison of type 1 angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors in the treatment of hypertension. J. Hypertens. 1997; 15: S31-S36.
8. Littlejohn T., Mroczek W., Marbury T. et al.: A prospective, randomized, open-label trial comparing telmisartan 80 mg and valsartan 80 mg in patients with mild to moderate hypertension using ambulatory blood pressure monitoring. Can. J. Cardiol. 2000; 16: 1123-1132.
9. Viberti G., Wheeldon N.M.; MicroAlbuminuria Reduction With VALsartan (MARVAL) Study Investigators: Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. Circulation 2002; 106: 672-678.
10. Vardeny O., Miller R., Solomon S.D.: Combined neprilysin and renin–angiotensin system inhibition for the treatment of heart failure. JACC Heart Fail. 2014; 2: 663-670.
11. Packer M., McMurray J.J.V., Desai A.S. et al.; on behalf of the PARADIGM-HF Investigators and Coordinators: Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure. Circulation 2015; 131: 54-61.
12. Ponikowski P., Voors A., Anker S. et al.: 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Eur. Heart J. 2016; 37: 2129-2200.
2. Flesch G., Muller P., Lloyd P.: Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist in man. Eur. J. Clin. Pharmcol. 1997; 52: 115-120.
3. Julius S., Kjeldsen S.E., Weber M. et al.; for the VALUE trial group: Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomized trial. Lancet 2004; 363: 2022-2031.
4. Kjeldsen S.E., Julius S., Mancia G. et al.: Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial. J. Hypertens. 2006; 24: 1405-1412.
5. Pfeffer M.A., McMurray J.J.V., Velazquez E.J. et al.: Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N. Engl. J. Med. 2003; 349: 1893-1906.
6. Mistry N.B., Westheim A.S., Kjeldsen S.E.: The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials. Expert Opin. Pharmacother. 2006; 7: 575-581.
7. Weber M.A.: Comparison of type 1 angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors in the treatment of hypertension. J. Hypertens. 1997; 15: S31-S36.
8. Littlejohn T., Mroczek W., Marbury T. et al.: A prospective, randomized, open-label trial comparing telmisartan 80 mg and valsartan 80 mg in patients with mild to moderate hypertension using ambulatory blood pressure monitoring. Can. J. Cardiol. 2000; 16: 1123-1132.
9. Viberti G., Wheeldon N.M.; MicroAlbuminuria Reduction With VALsartan (MARVAL) Study Investigators: Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. Circulation 2002; 106: 672-678.
10. Vardeny O., Miller R., Solomon S.D.: Combined neprilysin and renin–angiotensin system inhibition for the treatment of heart failure. JACC Heart Fail. 2014; 2: 663-670.
11. Packer M., McMurray J.J.V., Desai A.S. et al.; on behalf of the PARADIGM-HF Investigators and Coordinators: Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure. Circulation 2015; 131: 54-61.
12. Ponikowski P., Voors A., Anker S. et al.: 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Eur. Heart J. 2016; 37: 2129-2200.