Trimethoprim in the treatment of urinary tract infections – guidelines review Review article
Article Sidebar
Published:
Dec 31, 2017
Keywords:
urinary tract infections, trimethoprim, antibiotic prophylaxis
Main Article Content
Abstract
Introduction: Urinary tract infections remain one of the most common reasons of prescribing antibiotics. Even though we have clear guidelines for treatment of every kind of infections and the time of their usage, carried out studies suggest that the administrated treatment have a huge heterogeneity.
Aim: To summarize the available guidelines and identify the role of trimethoprim in the treatment of urinary tract infections.
Methods: Major guidelines were analyzed, including: Urological Infections by European Association of Urology (EAU), Guidelines from Center for Disease Control and Prevention (CDC), Infectious Diseases Society of America (IDSA), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), as well as Management of infection guidance for primary care for consultation and local adaptation by Public Health England (PHE).
Conclusions: Trimethoprim remains an effective antibiotic in the treatment of uncomplicated urinary tract infections, per surgical prophylaxis and selected other urinary tract infections.
Article Details
How to Cite
Ostrowski, A., & Drewa, T. (2017). Trimethoprim in the treatment of urinary tract infections – guidelines review. Medycyna Faktow (J EBM), 10(4(37), 308-312. https://doi.org/10.24292/01.MF.0417.2
Issue
Section
Articles
Copyright © by Medical Education. All rights reserved.
References
1. Huang E.S., Stafford R.S.: National patterns in the treatment of urinary tract infections in women by ambulatory care physicians. Arch. Intern. Med. 2002; 162(1): 41-47.
2. Horan T.C., Andrus M., Dudeck M.A.: CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am. J. Infect. Control. 2008; 36(5): 309-332.
3. Rubin R.H., Shapiro E.D., Andriole V.T.: Evaluation of new anti-infective drugs for the treatment of urinary tract infection. Infectious Diseases Society of America and the Food and Drug Administration. Clin. Infect. Dis. 1992; 15(Suppl. 1): S216-S227.
4. Gupta K., Hooton T.M., Naber K.G. et al.: International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin. Infect Dis. 2011; 52(5): e103-e120.
5. Brogden R.N., Carmine A.A., Heel R.C. et al.: Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs 1982; 23(6): 405-430.
6. Cai T., Mazzoli S., Mondaini N. et al.: The role of asymptomatic bacteriuria in young women with recurrent urinary tract infections: to treat or not to treat? Clin. Infect. Dis. 2012; 55(6): 771-777.
7. Tencer J.: Asymptomatic bacteriuria – a long-term study. Scand. J. Urol. Nephrol. 1988; 22(1): 31-34.
8. Zhanel G.G., Harding G.K., Nicolle L.E.: Asymptomatic bacteriuria in patients with diabetes mellitus. Rev. Infect. Dis. 1991; 13(1): 150-154.
9. Harding G.K., Zhanel G.G., Nicolle L.E. et al.: Antimicrobial treatment in diabetic women with asymptomatic bacteriuria. N. Engl. J. Med. 2002; 347(20): 1576-1583.
10. Mody L., Juthani-Mehta M.: Urinary tract infections in older women: a clinical review. JAMA 2014; 311(8): 844-854.
11. Nicolle L.E.: Urinary tract infections in patients with spinal injuries. Curr. Infect. Dis. Rep. 2014; 16(1): 390.
12. Wullt B., Holst E., Steven K. et al.: Microbial flora in ileal and colonic neobladders. Eur. Urol. 2004; 45(2): 233-239.
13. Wullt B., Agace W., Mansson W.: Bladder, bowel and bugs-bacteriuria in patients with intestinal urinary diversion. World J. Urol. 2004; 22(3): 186-195.
14. Tenke P., Kovacs B., Bjerklund Johansen T.E. et al.: European and Asian guidelines on management and prevention of catheter-associated urinary tract infections. Int. J. Antimicrob. Agents 2008; 31(Suppl. 1): S68-S78.
15. El Amari E.B., Hadaya K., Buhler L. et al.: Outcome of treated and untreated asymptomatic bacteriuria in renal transplant recipients. Nephrol. Dial. Transplant. 2011; 26(12): 4109-4114.
16. Ouslander J.G., Schapira M., Schnelle J.F. et al.: Does eradicating bacteriuria affect the severity of chronic urinary incontinence in nursing home residents? Ann. Intern. Med. 1995; 122(10): 749-754.
17. Grabe M., Forsgren A., Hellsten S.: The effect of a short antibiotic course in transurethral prostatic resection. Scand. J. Urol. Nephrol. 1984; 18(1): 37-42.
18. Widmer M., Lopez I., Gulmezoglu A.M. et al.: Duration of treatment for asymptomatic bacteriuria during pregnancy. Cochrane Database Syst. Rev. 2015; (11): CD000491.
19. Gupta K., Stamm W.E.: Outcomes associated with trimethoprim/sulphamethoxazole (TMP/SMX) therapy in TMP/SMX resistant community-acquired UTI. Int. J. Antimicrob. Agents 2002; 19(6): 554-556.
20. Warren J.W., Abrutyn E., Hebel J.R. et al.: Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin. Infect. Dis. 1999; 29(4): 745-758.
21. Hooton T.M., Scholes D., Gupta K. et al.: Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial. JAMA 2005; 293(8): 949-955.
22. Hooton T.M., Roberts P.L., Stapleton A.E.: Cefpodoxime vs ciprofloxacin for short-course treatment of acute uncomplicated cystitis: a randomized trial. JAMA 2012; 307(6): 583-589.
23. Wagenlehner F.M., Wullt B., Perletti G.: Antimicrobials in urogenital infections. Int. J. Antimicrob. Agents 2011; 38 Suppl.: 3-10.
24. Weidner W., Schiefer H.G., Krauss H. et al.: Chronic prostatitis: a thorough search for etiologically involved microorganisms in 1,461 patients. Infection 1991; 19(Suppl. 3): S119-S125.
25. Gill B.C., Shoskes D.A.: Bacterial prostatitis. Curr. Opin. Infect. Dis. 2016; 29(1): 86-91.
2. Horan T.C., Andrus M., Dudeck M.A.: CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am. J. Infect. Control. 2008; 36(5): 309-332.
3. Rubin R.H., Shapiro E.D., Andriole V.T.: Evaluation of new anti-infective drugs for the treatment of urinary tract infection. Infectious Diseases Society of America and the Food and Drug Administration. Clin. Infect. Dis. 1992; 15(Suppl. 1): S216-S227.
4. Gupta K., Hooton T.M., Naber K.G. et al.: International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin. Infect Dis. 2011; 52(5): e103-e120.
5. Brogden R.N., Carmine A.A., Heel R.C. et al.: Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs 1982; 23(6): 405-430.
6. Cai T., Mazzoli S., Mondaini N. et al.: The role of asymptomatic bacteriuria in young women with recurrent urinary tract infections: to treat or not to treat? Clin. Infect. Dis. 2012; 55(6): 771-777.
7. Tencer J.: Asymptomatic bacteriuria – a long-term study. Scand. J. Urol. Nephrol. 1988; 22(1): 31-34.
8. Zhanel G.G., Harding G.K., Nicolle L.E.: Asymptomatic bacteriuria in patients with diabetes mellitus. Rev. Infect. Dis. 1991; 13(1): 150-154.
9. Harding G.K., Zhanel G.G., Nicolle L.E. et al.: Antimicrobial treatment in diabetic women with asymptomatic bacteriuria. N. Engl. J. Med. 2002; 347(20): 1576-1583.
10. Mody L., Juthani-Mehta M.: Urinary tract infections in older women: a clinical review. JAMA 2014; 311(8): 844-854.
11. Nicolle L.E.: Urinary tract infections in patients with spinal injuries. Curr. Infect. Dis. Rep. 2014; 16(1): 390.
12. Wullt B., Holst E., Steven K. et al.: Microbial flora in ileal and colonic neobladders. Eur. Urol. 2004; 45(2): 233-239.
13. Wullt B., Agace W., Mansson W.: Bladder, bowel and bugs-bacteriuria in patients with intestinal urinary diversion. World J. Urol. 2004; 22(3): 186-195.
14. Tenke P., Kovacs B., Bjerklund Johansen T.E. et al.: European and Asian guidelines on management and prevention of catheter-associated urinary tract infections. Int. J. Antimicrob. Agents 2008; 31(Suppl. 1): S68-S78.
15. El Amari E.B., Hadaya K., Buhler L. et al.: Outcome of treated and untreated asymptomatic bacteriuria in renal transplant recipients. Nephrol. Dial. Transplant. 2011; 26(12): 4109-4114.
16. Ouslander J.G., Schapira M., Schnelle J.F. et al.: Does eradicating bacteriuria affect the severity of chronic urinary incontinence in nursing home residents? Ann. Intern. Med. 1995; 122(10): 749-754.
17. Grabe M., Forsgren A., Hellsten S.: The effect of a short antibiotic course in transurethral prostatic resection. Scand. J. Urol. Nephrol. 1984; 18(1): 37-42.
18. Widmer M., Lopez I., Gulmezoglu A.M. et al.: Duration of treatment for asymptomatic bacteriuria during pregnancy. Cochrane Database Syst. Rev. 2015; (11): CD000491.
19. Gupta K., Stamm W.E.: Outcomes associated with trimethoprim/sulphamethoxazole (TMP/SMX) therapy in TMP/SMX resistant community-acquired UTI. Int. J. Antimicrob. Agents 2002; 19(6): 554-556.
20. Warren J.W., Abrutyn E., Hebel J.R. et al.: Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin. Infect. Dis. 1999; 29(4): 745-758.
21. Hooton T.M., Scholes D., Gupta K. et al.: Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial. JAMA 2005; 293(8): 949-955.
22. Hooton T.M., Roberts P.L., Stapleton A.E.: Cefpodoxime vs ciprofloxacin for short-course treatment of acute uncomplicated cystitis: a randomized trial. JAMA 2012; 307(6): 583-589.
23. Wagenlehner F.M., Wullt B., Perletti G.: Antimicrobials in urogenital infections. Int. J. Antimicrob. Agents 2011; 38 Suppl.: 3-10.
24. Weidner W., Schiefer H.G., Krauss H. et al.: Chronic prostatitis: a thorough search for etiologically involved microorganisms in 1,461 patients. Infection 1991; 19(Suppl. 3): S119-S125.
25. Gill B.C., Shoskes D.A.: Bacterial prostatitis. Curr. Opin. Infect. Dis. 2016; 29(1): 86-91.