How vitamin D affects immunity? Review article

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Published: Mar 31, 2018
DOI: https://doi.org/10.24292/01.MF.0118.12
Keywords:
vitamin D, immunological response, cathelicidin, defensines

Main Article Content

Aleksandra Kucharczyk
Klinika Chorób Wewnętrznych, Pneumonologii, Alergologii i Immunologii Klinicznej, Wojskowy Instytut Medyczny
Witold Tłustochowicz
Klinika Chorób Wewnętrznych i Reumatologii, Wojskowy Instytut Medyczny, Centralny Szpital Kliniczny MON

Abstract

Vitamin D historically has been linked with homeostasis of the skeletal system. However, since it was found that the vitamin D receptors are on the majority of nucleated cells, research has begun on the function it performs in various organs, including the immune system. The available observations and results of numerous clinical studies confirm that vitamin D is fully relevant in both the innate and acquired immunological response. It affects, for example, the increase in cathelicidin and defensins responsible for local immunity. In the case of acquired immunity 1.25(OH)2D3 exerts a suppressive action and leads to the passage of the immune system from the pro-inflammatory to more tolerogenic, e.g. by affecting the regulatory T cells (Treg) and the Th17 lymphocytes. Active vitamin D also affects antigen presenting cells, such as dendrycytes, leading to changes in their function and morphology, and inhibiting their differentiation. Clinical observations also confirm the effect of vitamin D on immunity. In one study, it was noted that its supplementation reduced the number of patients with one infection, especially if the initial concentration of this vitamin was very low. Currently, a lot of randomized trials are under way to assess the possible beneficial effect of vitamin D supplementation on infectious diseases as well as cancer and autoimmune diseases. Their results will allow a full assessment of the significance of 1.25(OH)2D3 in these diseases.

Article Details

How to Cite
Kucharczyk, A., & Tłustochowicz , W. (2018). How vitamin D affects immunity?. Medycyna Faktow (J EBM), 11(1(38), 76-80. https://doi.org/10.24292/01.MF.0118.12
Issue
Vol 11 No 1(38) (2018)
Section
Articles

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