The role of zolpidem in the treatment of insomnia Review article
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Abstract
Sleep disturbances, especially insomnia, affecting between 5–20% the adult population, may be defined as the experience of inadequate quality and quantity of sleep together with negative daytime consequences. Insomniacs are treated with psychotherapeutic, pharmacological, and behavioral approaches. Non-benzodiazepine hypnotics, binds selectivity α1 subunits of the GABAA receptor, especially zolpidem, have been approved for short-term treatment of primary insomnia, have confirmed higher efficacy in comparing to trazodone, safety and good tolerance and – in contrast to benzodiazepines – they shown an absence of tolerance and have no practically dependence potential. Zolpidem does not have active metabolites and does not accumulate during repeated administration.
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