Lacosamide in the treatment of epilepsy – a case’s report Case series report
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Published:
Dec 31, 2019
Keywords:
lacosamide, epilepsy, combinations of antileptic drugs, pharmacokinetic profile
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Abstract
Lacosamide is a new generation anticonvulsant whose mechanism of action is thought to involve enhancement of slow inactivation of sodium channels. Lacosamid has a favourable pharmacokinetic profile including low protein binding, a long half-life and good bioavailability that is not affected by food intake. Additionally the lack of induction or inhibition of hepatic CYP family indicate a low potential for clinically significance drug-drug interactions. Weight neutrality and absent skin rashes are favourable features of the drug.
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How to Cite
Czapiński , P. (2019). Lacosamide in the treatment of epilepsy – a case’s report. Medycyna Faktow (J EBM), 12(4(45), 326-330. https://doi.org/10.24292/01.MF.0419.3
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References
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2. Beydoun A., D’Souza J., Hebert D.: Lacosamide: pharmacology, mechanics of action and pooled efficacy and safety data in partial-onset seizures. Expert Rev. 2009; 9(1): 33-42.
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5. Errington A., Stöhr T., Heers C. et al.: The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels. Mol. Pharmacol. 2008; 73(1): 157-169.
6. Ben-Menachem E., Biton V., Jatuzis D. et al.: Efficacy and Safety of Oral Lacosamide as Adjunctive Therapy in Adults with Partial-Onset Seizures. Epilepsia 2007; 48(7): 1308-1317.
7. Halasz P., Kälviäinen R., Mazurkiewicz-Beldzińska M. et al.: Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial. Epilepsia 2009; 50(3): 443-453.
8. Halford J., Lapointe M.: Clinical Perspectives on Lacosamide. Epilepsy Currents. 2009; 9(1): 1-9.
9. Villanueva V., Lopez-Gamariz E., Lopez-Trigo J. et al.: Rational polytherapy with lacosamide in clinical practise: results of a Spanish Cohort analysis RELACOVA. Epilepsy Behav. 2012; 23(3): 298-304.
10. Villanueva V., Lopez F., Serratosa J. et al.: Control of seizures in different stages of partial epilepsy: LACO-EXP, a Spanish retrospective study of lacosamide. Epilepsy Behav. 2013; 29: 349-356.
11. Villanueva V., Garces M., Lopez-Gomariz E. et al.: Early Add-on Lacosamide in a Real-Life Setting: Results of the REALLY Study. Clin. Drug Investig. 2015; 35: 121-131.
12. Czapinski P., Czapinska-Ciepiela E.: A prospective analysis of the effectiveness and tolerance of lacosamide in patients with refractory partial epilepsy. Epilepsia 2016; 57(suppl. 2): 167.
2. Beydoun A., D’Souza J., Hebert D.: Lacosamide: pharmacology, mechanics of action and pooled efficacy and safety data in partial-onset seizures. Expert Rev. 2009; 9(1): 33-42.
3. Cross S., Curran M.: Lacosamide In Partial-Onset Seizures. Drugs 2009; 69(4): 449-459.
4. Doty P., Rudd D., Stoehr T. et al.: Lacosamide. Neurotherapeutics 2007; 4: 145-148.
5. Errington A., Stöhr T., Heers C. et al.: The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels. Mol. Pharmacol. 2008; 73(1): 157-169.
6. Ben-Menachem E., Biton V., Jatuzis D. et al.: Efficacy and Safety of Oral Lacosamide as Adjunctive Therapy in Adults with Partial-Onset Seizures. Epilepsia 2007; 48(7): 1308-1317.
7. Halasz P., Kälviäinen R., Mazurkiewicz-Beldzińska M. et al.: Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial. Epilepsia 2009; 50(3): 443-453.
8. Halford J., Lapointe M.: Clinical Perspectives on Lacosamide. Epilepsy Currents. 2009; 9(1): 1-9.
9. Villanueva V., Lopez-Gamariz E., Lopez-Trigo J. et al.: Rational polytherapy with lacosamide in clinical practise: results of a Spanish Cohort analysis RELACOVA. Epilepsy Behav. 2012; 23(3): 298-304.
10. Villanueva V., Lopez F., Serratosa J. et al.: Control of seizures in different stages of partial epilepsy: LACO-EXP, a Spanish retrospective study of lacosamide. Epilepsy Behav. 2013; 29: 349-356.
11. Villanueva V., Garces M., Lopez-Gomariz E. et al.: Early Add-on Lacosamide in a Real-Life Setting: Results of the REALLY Study. Clin. Drug Investig. 2015; 35: 121-131.
12. Czapinski P., Czapinska-Ciepiela E.: A prospective analysis of the effectiveness and tolerance of lacosamide in patients with refractory partial epilepsy. Epilepsia 2016; 57(suppl. 2): 167.