7 reasons why diphenhydramine should be used to relieve transient sleep disorders Review article
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Published:
Dec 31, 2019
Keywords:
diphenhydramine, insomnia treatment, mild temporary sleep disturbances
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Abstract
Diphenhydramine is an anti-histaminic first-generation drug of sedative effect. It is considered alternative option of treatment of temporary sleep disturbances. It has no potential addictive properties and in some counties is available over the counter.
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How to Cite
Skalski, M. (2019). 7 reasons why diphenhydramine should be used to relieve transient sleep disorders. Medycyna Faktow (J EBM), 12(4(45), 318-322. https://doi.org/10.24292/01.MF.0419.2
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References
1. Carruthers S.G., Shoeman D.W., Hignite C.E., Azarnoff D.L.: Correlation between plasma diphenhydramine level and sedative and antihistamine effects. Clin. Pharm. Ther. 1978; 23(4): 375-382.
2. Glazko A.J., Dill W.A., Young R.M. et al.: Metabolic disposition of diphenhydramine. Clin. Pharmacol. Ther. 1974; 16(6): 1066-1076.
3. Simons F.E.R., Simons K.J.: Histamine and H1-antihistamines: Celebrating a century of progress. J. Allergy Clin. Immunol. 2011; 128(6): 1139-1150.e4.
4. Skalski M.: Zaburzenia snu w codziennej praktyce. Wyd. 2. Medical Tribune, Warszawa 2018.
5. Cooper S., Laurora I., Wang Y. et al.: Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia. Int. J. Clin. Pract. 2015; 69(10): 1149-1158.
6. Kudo Y., Kurihara M.: Clinical evaluation of diphenhydramine hydrochloride for the treatment of insomnia in psychiatric patients: a double- blind study. J. Clin. Pharmacol. 1990; 30(11): 1041-1048.
7. Morin C.M., Koette U., Bastien C. et al.: Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005; 28(11): 1465-1471.
8. Rickels K., Morris R.J., Newman H. et al.: Diphenhydramine in insomniac family practice patients: a double-blind study. J. Clin. Pharmacol. 1983; 23(5-6): 234-242.
9. Gengo F.M., Manning C.: A review of the effects of antihistamines on mental processes related to automobile driving. J. Allergy Clin. Immunol. 1990; 86(6): 1034-1039.
10. Ramaekers J.G., O’Hanlon J.F.: Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing. Eur. J. Clin. Pharmacol. 1994; 47(3): 261-266.
11. Verster J.C., de Veert A.M., Bijtjes S.I. et al.: Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial. Psychopharmacology 2003; 169(1): 84-90.
12. [online: www.leki-informacje.pl].
13. Apap Noc – ulotka – Rejestr produktów leczniczych. Dostęp: 3.06.2019.
14. Culpepper L., Wingertzahn M.A.: Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety. Prim. Care Companion. CNS Disord. 2015; 17(6): 10.4088/PCC.15r01798. DOI: 10.4088/PCC.15r01798.
15. Friedman B.W., Cabral L., Adevunmi V. et al.: Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial. Ann. Emerg. Med. 2016; 67(1): 32-39.e3.
16. Lin R.Y., Curry A., Pesola G.R. et al.: Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann. Emerg. Med. 2000; 36(5): 462-468.
17. Paul I.M., Yoder K.E., Crowell K.R. et al.: Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004; 114(1): e85-90.
18. Swidan S.Z., Lake A.E., Saper J.R.: Efficacy of intravenous diphenhydramine versus intravenous DHE-45 in the treatment of severe migraine headache. Curr. Pain Head. Rep. 2005; 9(1): 65-70.
19. Thormann M., Amthauer H., Adolf D. et al.: Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI. Eur. J. Radiol. 2013; 82(5): 768-772.
20. Yoder K.E., Shaffer M.L., La Tournous S.J., Paul I.M.: Child Assessment of Dextromethorphan, Diphenhydramine, and Placebo for Nocturnal Cough Due to Upper Respiratory Infection. Clin. Pediatr. 2006; 45(7): 633-640.
21. Cengiz M., Baysal Z., Ganidagli S.: Oral sedation with midazolam and diphenhydramine compared with midazolam alone in children undergoing magnetic resonance imaging. Paediatr. Anaesth. 2006; 16(6): 621-626.
22. Glass J.R., Sproule B.A., Herrmann N., Busto U.E.: Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial. J. Clin. Psychopharmacol. 2008; 28(2): 182-188.
23. Hryniewicz W., Albrecht P., Radzikowski A. (red.): Narodowy Program Ochrony Antybiotyków. Rekomendacje postępowania w zakażeniach układu oddechowego. Narodowy Program Ochrony Antybiotyków. Warszawa 2016.
24. Merenstein D., Diener-West M., Halbower A.C. et al.: The trial of infant response to diphenhydramine: the TIRED study – a randomized, controlled, patient-oriented trial. Arch. Pediatr. Adolesc. Med. 2006; 160(7): 707-712.
25. Yangzom N., Gottschlich M.M., Ossege J. et al.: The Effect of Diphenhydramine on Sleep in Pediatric Burn Patients: A Secondary Analysis. J. Burn Care Res. 2015; 36(2): 266-271.
2. Glazko A.J., Dill W.A., Young R.M. et al.: Metabolic disposition of diphenhydramine. Clin. Pharmacol. Ther. 1974; 16(6): 1066-1076.
3. Simons F.E.R., Simons K.J.: Histamine and H1-antihistamines: Celebrating a century of progress. J. Allergy Clin. Immunol. 2011; 128(6): 1139-1150.e4.
4. Skalski M.: Zaburzenia snu w codziennej praktyce. Wyd. 2. Medical Tribune, Warszawa 2018.
5. Cooper S., Laurora I., Wang Y. et al.: Efficacy and tolerability studies evaluating a sleep aid and analgesic combination of naproxen sodium and diphenhydramine in the dental impaction pain model in subjects with induced transient insomnia. Int. J. Clin. Pract. 2015; 69(10): 1149-1158.
6. Kudo Y., Kurihara M.: Clinical evaluation of diphenhydramine hydrochloride for the treatment of insomnia in psychiatric patients: a double- blind study. J. Clin. Pharmacol. 1990; 30(11): 1041-1048.
7. Morin C.M., Koette U., Bastien C. et al.: Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005; 28(11): 1465-1471.
8. Rickels K., Morris R.J., Newman H. et al.: Diphenhydramine in insomniac family practice patients: a double-blind study. J. Clin. Pharmacol. 1983; 23(5-6): 234-242.
9. Gengo F.M., Manning C.: A review of the effects of antihistamines on mental processes related to automobile driving. J. Allergy Clin. Immunol. 1990; 86(6): 1034-1039.
10. Ramaekers J.G., O’Hanlon J.F.: Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing. Eur. J. Clin. Pharmacol. 1994; 47(3): 261-266.
11. Verster J.C., de Veert A.M., Bijtjes S.I. et al.: Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial. Psychopharmacology 2003; 169(1): 84-90.
12. [online: www.leki-informacje.pl].
13. Apap Noc – ulotka – Rejestr produktów leczniczych. Dostęp: 3.06.2019.
14. Culpepper L., Wingertzahn M.A.: Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety. Prim. Care Companion. CNS Disord. 2015; 17(6): 10.4088/PCC.15r01798. DOI: 10.4088/PCC.15r01798.
15. Friedman B.W., Cabral L., Adevunmi V. et al.: Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department-Based Randomized Clinical Trial. Ann. Emerg. Med. 2016; 67(1): 32-39.e3.
16. Lin R.Y., Curry A., Pesola G.R. et al.: Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann. Emerg. Med. 2000; 36(5): 462-468.
17. Paul I.M., Yoder K.E., Crowell K.R. et al.: Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004; 114(1): e85-90.
18. Swidan S.Z., Lake A.E., Saper J.R.: Efficacy of intravenous diphenhydramine versus intravenous DHE-45 in the treatment of severe migraine headache. Curr. Pain Head. Rep. 2005; 9(1): 65-70.
19. Thormann M., Amthauer H., Adolf D. et al.: Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI. Eur. J. Radiol. 2013; 82(5): 768-772.
20. Yoder K.E., Shaffer M.L., La Tournous S.J., Paul I.M.: Child Assessment of Dextromethorphan, Diphenhydramine, and Placebo for Nocturnal Cough Due to Upper Respiratory Infection. Clin. Pediatr. 2006; 45(7): 633-640.
21. Cengiz M., Baysal Z., Ganidagli S.: Oral sedation with midazolam and diphenhydramine compared with midazolam alone in children undergoing magnetic resonance imaging. Paediatr. Anaesth. 2006; 16(6): 621-626.
22. Glass J.R., Sproule B.A., Herrmann N., Busto U.E.: Effects of 2-week treatment with temazepam and diphenhydramine in elderly insomniacs: a randomized, placebo-controlled trial. J. Clin. Psychopharmacol. 2008; 28(2): 182-188.
23. Hryniewicz W., Albrecht P., Radzikowski A. (red.): Narodowy Program Ochrony Antybiotyków. Rekomendacje postępowania w zakażeniach układu oddechowego. Narodowy Program Ochrony Antybiotyków. Warszawa 2016.
24. Merenstein D., Diener-West M., Halbower A.C. et al.: The trial of infant response to diphenhydramine: the TIRED study – a randomized, controlled, patient-oriented trial. Arch. Pediatr. Adolesc. Med. 2006; 160(7): 707-712.
25. Yangzom N., Gottschlich M.M., Ossege J. et al.: The Effect of Diphenhydramine on Sleep in Pediatric Burn Patients: A Secondary Analysis. J. Burn Care Res. 2015; 36(2): 266-271.