Commentary [to HYVET trial] Commentary
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Published:
Dec 31, 2008
Keywords:
hypertension, HYVET, elderly
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Abstract
The lack of evident data which would confirm the benefits of a hypotensive therapy for patients over 80 called for a large clinical trial that could answer numerous questions connected with hypertension of the elderly. HYVET trial has proved that the therapy based on indapamide or the combination of indapamide and perindopril reduces all cause mortality, stroke mortality, risk of cardiovascular incidents, and developments of heart failure at hypertensive over 80. The therapeutic scheme used in the trial is beneficial especially to the patients characterised by the risk profile close to the one observed with the trial participants.
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How to Cite
Czarnecka , D., & Kusiak , A. (2008). Commentary [to HYVET trial]. Medycyna Faktow (J EBM), 1(1(1), 23-26. Retrieved from https://journalsmededu.pl/index.php/jebm/article/view/1802
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References
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2. Boshuizen H.C., Izaks G.J., van Buuren S., Ligthart G.J.: Blood pressure and mortality in elderly people aged 85 and older: community based study. B.M.J. 1998; 316(7147): 1780-4.
3. SHEP Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. JAMA 1991; 265: 3255-3264.
4. Forette F., Seux M.L., Staessen J.A. et al.: Prevention of dementia in randomised double-blind placebo controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998; 352: 1347-51.
5. Gueyffier F., Bulpitt C., Boissel J.P. et al.: Antihypertensive drugs in very old people: a subgroup meta-analysis of randomized controlled trials. INDANA group. Lancet 1999; 353: 793-796.
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