Racekadotryl w leczeniu ostrej biegunki u dzieci: co mówią dane naukowe? Artykuł przeglądowy
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Opublikowane:
cze 20, 2022
Słowa kluczowe:
ostra biegunka, nieżyt żołądkowo-jelitowy, leki przeciwbiegunkowe
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Abstrakt
Ostra biegunka infekcyjna, czyli nieżyt żołądkowo-jelitowy (gastroenterocolitis), pozostaje jedną z częstych chorób wieku dziecięcego. Odwodnienie w przebiegu ostrej biegunki jest najczęstszym i jednym z najpoważniejszych powikłań. Podstawę leczenia stanowi więc stosowanie doustnych płynów nawadniających (lub nawadnianie dożylne, w zależności od stopnia odwodnienia). Doustne płyny nawadniające nie wpływają jednak na czas trwania i nasilenie biegunki, stąd zainteresowanie farmakoterapią. Racekadotryl jest lekiem o działaniu antysekrecyjnym, który wywiera działanie poprzez hamowanie enkefalinaz. W artykule omówiono aktualne dane dotyczące roli racekadotrylu w leczeniu ostrej biegunki u dzieci.
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Jak cytować
Szajewska , H. (2022). Racekadotryl w leczeniu ostrej biegunki u dzieci: co mówią dane naukowe? . Medycyna Faktów , 15(2(55), 130-135. https://doi.org/10.24292/01.MF.0222.2
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Bibliografia
1. Guarino A, Ashkenazi S, Gendrel D et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014; 59: 132-52.
2. Shane A, Mody R, Crump J et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. Clin Infect Dis. 2017; 65: 1963-73.
3. Guarino A, Lo Vecchio A, Dias JA et al. Universal Recommendations for the Management of Acute Diarrhea in Nonmalnourished Children. J Pediatr Gastroenterol Nutr. 2018; 67: 586-93.
4. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000; 14: 75-9.
5. Baumer P, Danquechin Dorval E, Bertrand J et al. Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea. Gut. 1992; 33: 753-8.
6. Hinterleitner TA, Petritsch W, Dimsity G et al. Acetorphan prevents cholera-toxin-induced water and electrolyte secretion in the human jejunum. Eur J Gastroenterol Hepatol. 1997; 9: 887-91.
7. Gordon M, Akobeng A. Racecadotril for acute diarrhoea in children: systematic review and meta-analyses. Arch Dis Child. 2016; 101(3): 234-40.
8. Liang Y, Zhang L, Zeng L et al. Racecadotril for acute diarrhoea in children. Cochrane Database Syst Rev. 2019; 12: CD009359.
9. Eberlin M, Chen M, Mueck T et al. Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. BMC Pediatr. 2018; 18(1): 124. http://doi.org/10.1186/s12887-018-1095-x.
10. Mahraoui L, Heyman M, Plique O et al. Apical effect of diosmectite on damage to the intestinal barrier induced by basal tumour necrosis factor-alpha. Gut. 1997; 40: 339-43.
11. Turck D, Berard H, Fretault N et al. Comparison of racecadotril and loperamide in children with acute diarrhoea. Aliment Pharmacol Ther. 1999; 13(suppl 6): 27-32.
12. Chung KT, Stevens SE Jr, Lin WF et al. Growth inhibition of selected foodborne bacteria by tannic acid, propyl gallate andrelated compounds. Lett Appl Microbiol. 1993; 17: 29-32.
13. Scalbert A. Antimicrobial properties of tannins. Phytochemistry. 1991; 30: 3875-83.
14. Frasca G, Cardile V, Puglia C et al. Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells. Clin Exp Gastroenterol. 2012; 5: 61-7.
15. Florez ID, Sierra JM, Niño-Serna LF. Gelatin tannate for acute diarrhoea and gastroenteritis in children: a systematic review and meta-analysis. Arch Dis Child. 2020; 105: 141-6.
16. Kołodziej M, Bebenek D, Konarska Z et al. Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial. BMJ Open. 2018; 8(5): e020205.
17. Baumer P. Racecadotril: side effects and tolerability. In: Manfredi M (ed). Racecadotril: an effective anti-diarrheal drug. Nova Science Pub Inc. 2020: 211-37.
18. Rautenberg TA, Zerwes U, Lee WS. Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia. Clinicoecon Outcomes Res. 2018; 10: 169-78.
19. Rautenberg TA, Zerwes U. The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand. Clinicoecon Outcomes Res. 2017; 9: 411-22.
20. Rautenberg TA, Zerwes U, Foerster D et al. Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: the RAWD model. Clinicoecon Outcomes Res. 2012; 4: 109-16.
21. Pienar C, Benninga MA, Broekaert IJ et al. Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease. J Pediatr Gastroenterol Nutr. 2020; 70(2): 162-4.
2. Shane A, Mody R, Crump J et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. Clin Infect Dis. 2017; 65: 1963-73.
3. Guarino A, Lo Vecchio A, Dias JA et al. Universal Recommendations for the Management of Acute Diarrhea in Nonmalnourished Children. J Pediatr Gastroenterol Nutr. 2018; 67: 586-93.
4. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000; 14: 75-9.
5. Baumer P, Danquechin Dorval E, Bertrand J et al. Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea. Gut. 1992; 33: 753-8.
6. Hinterleitner TA, Petritsch W, Dimsity G et al. Acetorphan prevents cholera-toxin-induced water and electrolyte secretion in the human jejunum. Eur J Gastroenterol Hepatol. 1997; 9: 887-91.
7. Gordon M, Akobeng A. Racecadotril for acute diarrhoea in children: systematic review and meta-analyses. Arch Dis Child. 2016; 101(3): 234-40.
8. Liang Y, Zhang L, Zeng L et al. Racecadotril for acute diarrhoea in children. Cochrane Database Syst Rev. 2019; 12: CD009359.
9. Eberlin M, Chen M, Mueck T et al. Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. BMC Pediatr. 2018; 18(1): 124. http://doi.org/10.1186/s12887-018-1095-x.
10. Mahraoui L, Heyman M, Plique O et al. Apical effect of diosmectite on damage to the intestinal barrier induced by basal tumour necrosis factor-alpha. Gut. 1997; 40: 339-43.
11. Turck D, Berard H, Fretault N et al. Comparison of racecadotril and loperamide in children with acute diarrhoea. Aliment Pharmacol Ther. 1999; 13(suppl 6): 27-32.
12. Chung KT, Stevens SE Jr, Lin WF et al. Growth inhibition of selected foodborne bacteria by tannic acid, propyl gallate andrelated compounds. Lett Appl Microbiol. 1993; 17: 29-32.
13. Scalbert A. Antimicrobial properties of tannins. Phytochemistry. 1991; 30: 3875-83.
14. Frasca G, Cardile V, Puglia C et al. Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells. Clin Exp Gastroenterol. 2012; 5: 61-7.
15. Florez ID, Sierra JM, Niño-Serna LF. Gelatin tannate for acute diarrhoea and gastroenteritis in children: a systematic review and meta-analysis. Arch Dis Child. 2020; 105: 141-6.
16. Kołodziej M, Bebenek D, Konarska Z et al. Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial. BMJ Open. 2018; 8(5): e020205.
17. Baumer P. Racecadotril: side effects and tolerability. In: Manfredi M (ed). Racecadotril: an effective anti-diarrheal drug. Nova Science Pub Inc. 2020: 211-37.
18. Rautenberg TA, Zerwes U, Lee WS. Cost utility, budget impact, and scenario analysis of racecadotril in addition to oral rehydration for acute diarrhea in children in Malaysia. Clinicoecon Outcomes Res. 2018; 10: 169-78.
19. Rautenberg TA, Zerwes U. The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand. Clinicoecon Outcomes Res. 2017; 9: 411-22.
20. Rautenberg TA, Zerwes U, Foerster D et al. Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: the RAWD model. Clinicoecon Outcomes Res. 2012; 4: 109-16.
21. Pienar C, Benninga MA, Broekaert IJ et al. Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease. J Pediatr Gastroenterol Nutr. 2020; 70(2): 162-4.