The prevalence of specific IgE antibodies against nuts components in adults
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Abstract
Food allergy affects Europe’s 11–26 million people. A particular challenge for allergists in the XXI century is allergy to nuts. It applies to 1.3% adults. Under the colloquial notion of allergy to nuts, hides two diseases, allergy to tree nuts, and peanut allergy. The aim of the study was to evaluate the IgE antibodies profile against nuts components in adults with suspected food allergy. The study was conducted at the Department of Allergology, Clinical Immunology and Internal Medicine in Bydgoszcz. The study was retrospective. 136 people were classified to study. The ImmunoCap ISAC test was performed to all patients. The antibodies against nut components were detected in 43 patients. Antibodies against tree nuts components were detected in all patients and peanut components in 2/3 subjects. In 43 respondents obtained 12 allergy profiles. In 35 patients antibodies against components responsible for cross-reaction with birch pollen were detected. In 17 patients antibodies against components responsible for anaphylaxis were detected and 60% of detected proteins belonged to walnut.
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
References
2. Sicherer S., Wood R., Savage J.: The Natural History of Food Allergy. J. Allergy Clin. Immunol. Pract. 2016, 4(2): 196-203.
3. Żbikowska-Gotz M., Bartuzi Z.: Diagnostyka alergii pokarmowej. X Międzynarodowy Kongres PTA, 7–10.10.2009.
4. Bartuzi Z.: Nowe spojrzenie na alergeny pokarmowe. Alergia 2011, 2: 31-37.
5. Flinterman A.E., Akkerdaas J.H., Knulst A.C. et al.: Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions. Curr. Opin. Allergy Clin. Immunol. 2008, 8(3): 261-265.
6. Schocker F., Lüttkopf D., Scheurer S. et al.: Recombinant lipid transfer protein Cor a 8 from hazelnut: a new tool for in vitro diagnosis of potentially severe hazelnut allergy. J. Allergy Clin. Immunol. 2004, 113(1): 141-147.
7. Vaughan J.G., Geissler C.A.: Rośliny jadalne. Prószyński i S-ka, Warszawa 2001.
8. Aalberse J.A., Meijer Y., Derksen N. et al.: Moving from peanut extract to peanut components: towards validation of component-resolved IgE test. Article first published online: 29 APR 2013.
9. Nicolaou N., Poorafshar M., Murray C. et al.: Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J. Allergy Clin. Immunol. 2010, 125(1): 191-197.
10. Chen X., Wang Q., El-Mezayen R. et al.: Ara h 2 and Ara h 6 have similar allergenic activity and are substantially redundant. Int. Arch. Allergy Immunol. 2013, 160: 251-258.
11. Napiórkowska K., Żbikowska-Gotz M., Bartuzi Z. et al.: Alergia krzyżowa pyłku brzozy z alergenami jabłka, selera oraz marchwi przy użyciu dostępnych metod diagnostycznych. Współczesna Alergia Info 2009, 4(2): 52-57.
12. Lauer I., Dueringer N., Pokoj S. et al.: The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut. Clin. Exp. Allergy 2009, 39: 1427-1437.
13. Downs M., Semic-Jusufagic A., Simpson A. et. al.: Importance Of High Molecular Weight Proteins In Walnut Allergy. J. Allergy Clin. Immunol. 2014, 133: AB115-AB115.
14. Asero R., Mistrello G., Roncarolo D. et al.: Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002, 57(10): 900-906.
15. Moreno F.J., Mellon F.A., Wickham M.S. et al.: Stability of the major allergen Brazil nut 2S albumin (Ber e 1) to physiologically relevant in vitro gastrointestinal digestion. FEBS J. 2005, 272(2): 341-352.
16. Grigg A.W., Hanson I.C., Davis C.M.: Cashew Allergy Demographics, Presentation and Cross Reactivity in a US Cohort. J. Allergy Clin. Immunol. 2007, 119: S121.
17. Barre A., Sordet C., Culerrier R. et al.: Vicilin allergens of peanut and tree nuts (walnut, hazelnut and cashew nut) share structurally related IgE-binding epitopes. Mol. Immunol. 2008, 45(5): 1231-1240.
18. Cianferoni A., Muraro A.: Food-Induced Anaphylaxis. Immunol. Allergy Clin. North Am. 2012, 32(1): 165-195.
19. Uotila R., Kukkonen A.K., Pelkonen A.S., Mäkelä M.J.: Cross-sensitization profiles of edible nuts in a birch-endemic area. Allergy 2016, 71(4): 514-521.
20. Goikoetxea M.J., D’Amelio C.M., Martínez-Aranguren R. et al.: Is Microarray Analysis Really Useful and Sufficient to Diagnose Nut Allergy in the Mediterranean Area? Investig. Allergol. Clin. Immunol. 2016, 26(1): 31-39.