Perspektywy immunoterapii chorób alergicznych III. Zastosowanie preparatów bakteryjnych i elementów mikroorganizmów w profilaktyce i leczeniu alergii
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Abstrakt
Kontakt z mikroorganizmami zarówno chorobotwórczymi, jak i niepatogennymi jest niezbędny do prawidłowego funkcjonowania układu odpornościowego. Wykładnikiem tego jest odpowiednie zbalansowanie czynności limfocytów pomocniczych Th1 i Th2. Różne drobnoustroje, a także pasożyty wielokomórkowe indukują odpowiedź immunologiczną, w którą preferencyjnie zaangażowane są limfocyty Th1 bądź Th2. Ponieważ w olbrzymiej większości chorób alergicznych związanych z nadprodukcją IgE aktywacja subpopulacji Th2 odgrywa dominującą rolę w etiopatogenezie, podejmowane są próby stosowania bakterii bądź elementów drobnoustrojów lub ich pochodnych działających aktywująco na subpopulację Th1 w celu zapobieżenia określonym schorzeniom alergicznym lub ich leczenia.
Pobrania
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
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