Akromegalia: wpływ analogów somatostatyny na zmniejszenie objętości guza przysadki Review article
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Abstrakt
Akromegalia to rzadka choroba spowodowana zwiększonym wydzielaniem hormonu wzrostu (GH) i wtórnie insulinopodobnego czynnika wzrostu typu 1 (IGF-1). W niemal wszystkich przypadkach wynika z obecności gruczolaka przysadki wywodzącego się z komórek somatotropowych. Celem leczenia akromegalii jest normalizacja stężeń GH i IGF-1, co zmniejsza nasilenie objawów choroby i jej powikłań oraz śmiertelność. Leczeniem z wyboru jest przezklinowa, selektywna adenomektomia wykonywana przez doświadczonego neurochirurga. Leczenie farmakologiczne analogami somatostatyny stosuje się w ramach przygotowania do leczenia neurochirurgicznego i terapii uzupełniającej w przypadku braku doszczętności operacji. Długo działające analogi somatostatyny obniżają wydzielanie GH i IGF-1 oraz zmniejszają objętość gruczolaka somatotropowego przysadki. W niniejszej pracy przedstawiono mechanizmy działania i znaczenie analogów somatostatyny I i II generacji w akromegalii ze szczególnym uwzględnieniem ich wpływu na zmniejszanie guza somatotropowego przysadki.
Pobrania
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Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa – Użycie niekomercyjne 4.0 Międzynarodowe.
Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
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