Severe vascular and neurological complications after hematopoietic stem cell transplantation with reduced intensity conditioning Case report

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Opublikowane: lut 19, 2019
DOI: https://doi.org/10.24292/01.OR.119190219
Słowa kluczowe:
fludarabine, ALLO-HSCT, reduced intensity conditioning, PRES, neurotoxcity

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Krzysztof Czyżewski
Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
Paulina Nierychlewska
Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
Monika Richert-Przygońska
Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
Jakub Cieściński
Department of Radiology and Diagnostic Imagining, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
Jan Styczyński
Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland

Abstrakt

It is well established that the benefit of myeloablative ALLO-HSCT can be associated with a potential high risk of procedure-related toxicity. The objective of this report is the analysis of complications in a 17-year-old girl with AML previously treated for medulloblastoma and myelodysplastic syndrome. Thiotepa, fludarabine, treosulfan and thymoglobuline were used in conditioning regimen. During conditioning neurological complications have occurred. MRI and CT scan results revealed the coexistence of PRES with the left internal carotid artery thrombosis. The effect of fludarabine on endothelial cells could possibly contribute to irreversible CNS damage and death in presented case.

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1.
Czyżewski K, Nierychlewska P, Richert-Przygońska M, Cieściński J, Styczyński J. Severe vascular and neurological complications after hematopoietic stem cell transplantation with reduced intensity conditioning. OncoReview [Internet]. 19 luty 2019 [cytowane 22 listopad 2024];9(1(33):27-0. Dostępne na: https://journalsmededu.pl/index.php/OncoReview/article/view/410
Numer
Tom 9 Nr 1(33) (2019)
Dział
HAEMATOLOGY IN ONCOLOGY
Creative Commons License

Utwór dostępny jest na licencji Creative Commons Uznanie autorstwa – Użycie niekomercyjne 4.0 Międzynarodowe.

Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)

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