Rola lapatynibu w leczeniu HER2-dodatniego raka piersi Artykuł przeglądowy
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Abstrakt
Rak piersi z nadekspresją receptora HER2 lub amplifikacją jego genu stanowi ok. 25–30% zachorowań i wiąże się z bardziej agresywnym przebiegiem i gorszym rokowaniem. Wprowadzenie trastuzumabu – pierwszego leku celowanego ukierunkowanego na zewnątrzkomórkową domenę receptora HER2 – poprawiło skuteczność leczenia. Mimo pierwotnej odpowiedzi na leczenie dochodzi do wytworzenia oporności i progresji choroby. Drugim lekiem wpływającym na receptor HER2 jest lapatynib. Nie stwierdzono krzyżowej oporności między obydwoma lekami. Lapatynib to odwracalny inhibitor kinazy tyrozynowej dwóch receptorów EGFR i HER2. Na podstawie badań klinicznych udowodniono jego skuteczność i bezpieczeństwo w leczeniu HER2-dodatniego raka piersi.
Pobrania
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Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)
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