Application of two lines of chemotherapy: gemcitabine with nab-paclitaxel and liposomal irinotecan with 5-fluorouracil and leucovorin in patient with advanced pancreatic adenocarcinoma Opis przypadku

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Opublikowane: lip 11, 2021
DOI: https://doi.org/10.24292/01.OR.123100721
Słowa kluczowe:
advanced pancreatic cancer, gemcitabine in combination with nab-paclitaxel, liposomal irinotecan with 5-FU/LV

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Krystyna Ostrowska-Cichocka
Department of Clinical Oncology with the Subdivision of Daily Chemotherapy, Dr. Ewa Pilecka Memorial Bialystok Cancer Center
Marek Z. Wojtukiewicz
1. Department of Clinical Oncology with the Subdivision of Daily Chemotherapy, Dr. Ewa Pilecka Memorial Bialystok Cancer Center. 2. Department of Oncology, Medical University of Bialystok

Abstrakt

Pancreatic cancer is a disease with high mortality. It is predicted to become the second leading cause of cancer death in some regions of the world. Frequent diagnosis at an advanced stage contributes to 5-year survival at a highly unsatisfactory level of 2–9%. Due to the lack of early symptoms, nearly 80% of patients receive a diagnosis when distant metastases develop. So far, the most frequently used programs in the treatment of patients with pancreatic cancer in the stage of neoplastic spreading include: FOLFIRINOX (oxaliplatin, 5-fluorouracil, irinotecan, leucovorin), gemcitabine alone or in combination with nab-paclitaxel or erlotinib.


Based on the results of the phase III study NAPOLI-1, liposomal irinotecan in combination with 5-fluorouracil (5-FU) and leucovorin (LV ) was approved as the first regimen for use in the second or subsequent line of therapy in patients with advanced pancreatic cancer previously treated with gemcitabine. This paper presents a case of a patient with advanced pancreatic cancer who was treated with two lines of chemotherapy – gemcitabine in combination with nab-paclitaxel and liposomal irinotecan with 5-FU/LV . The treatment was well tolerated and was considered a valuable therapeutic option. A 2-year overall survival was obtained from the diagnosis of the disease.

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1.
Ostrowska-Cichocka K, Wojtukiewicz MZ. Application of two lines of chemotherapy: gemcitabine with nab-paclitaxel and liposomal irinotecan with 5-fluorouracil and leucovorin in patient with advanced pancreatic adenocarcinoma. OncoReview [Internet]. 11 lipiec 2021 [cytowane 25 listopad 2024];11(3(43):68-2. Dostępne na: https://journalsmededu.pl/index.php/OncoReview/article/view/1517
Numer
Tom 11 Nr 3(43) (2021)
Dział
PERSONALIZED ONCOLOGY
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Address reprint requests to: Medical Education, Marcin Kuźma (marcin.kuzma@mededu.pl)

Bibliografia

1. Ducreux M, Cuhna A. Sa, Caramella C et al. Cancer of the pancreas: ESMO Clinical Practice.Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015; 26(suppl 5): v56-v68.
2. Lambert A, Schwarz L, Borbath I et al. An update on treatment options for pancreatic adenocarcinoma. Adv Med Oncol. 2019; 11: 1143.
3. McGuigan A, Kelly P, Turkington RC et al. Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 2018; 24(43): 4846-61.
4. Taieb J, Abdallah R. How I treat pancreatic cancer. ESMO Open. 2020; 4: e000818. https://doi.org/10.1136/.Esmo open-2020-0008.
5. Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007; 25: 1960-6.
6. Jassem J, Krzakowski M, Potemski P. Nowotwory układu pokarmowego. 2nd ed. Via Medica, Gdańsk 2019.
7. Conroy T, Desseigne F, Ychou M et al. FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer. N Engl J Med. 2011; 364: 1817-25.
8. Tempero MA, Malafa MP, Chiorean EG et al. Pancreatic adenocarcinoma, version 1.2021. NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2019; 17(3): 202-10.
9. Tehfe M, Dowden S, Kennecke H et al. nab-Paclitaxel Plus Gemcitabine Versus Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma: Canadian Subgroup Analysis of the Phase 3 MPACT Trial. Adv Ther. 2016; 33(5): 747-59.
10. Von Hoff DD, Ervin T, Arena FP et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013; 369: 1691-703.
11. Czyżykowski R, Janiak M, Krakowska M et al. Palliative systemic treatment of patients with pancreatic cancer – should reimbursement of nab-paclitaxel change the current management paradigm? Oncol Clin Pract. 2017; 13: 8-13.
12. Wang-Gillam A, Li C-P, Bodoky G et al. Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet. 2016; 387: 545-57.
13. Klank-Sokołowska E, Kucharewicz M, Wojtukiewicz MZ. Nanoliposomalny irynotekan – nowe perspektywy leczenia uogólnionego raka trzustki. Onkol Prakt Klin. 2019; 5: 1-9.