Tyrosine kinase inhibitors – should we worry about cardiovascular complications? Review article

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Published: Apr 2, 2017
DOI: https://doi.org/10.24292/01.OR.300617.3
Keywords:
small-molecular tyrosine kinase inhibitors, cardiotoxcity, anti-angiogenic therapy, cardiovascular events

Main Article Content

Katarzyna Styczkiewicz
Cardiology Department, Brzozow Hospital, Subcarpathian Cancer Center, Brzozow, Poland
Dariusz Sawka
Chemotherapy Department, Brzozow Hospital, Subcarpathian Cancer Center, Brzozow, Poland
Marek Styczkiewicz
Cardiology Department, Brzozow Hospital, Subcarpathian Cancer Center, Brzozow, Poland

Abstract

Drobnocząsteczkowe inhibitory kinaz tyrozynowych stanowią skuteczną opcję terapeutyczną dla pacjentów z nowotworami hematologicznymi i guzami litymi. Z drugiej strony, podkreśla się znaczenie sercowo-naczyniowych działań niepożądanych związanych z ich stosowaniem, takich jak: nadciśnienie tętnicze, niewydolność serca, choroba wieńcowa/ostre zespoły wieńcowe i wydłużenie odstępu QT. W niniejszej pracy omówiono mechanizmy leżące u podłoża zdarzeń sercowo-naczyniowych związanych z terapią inhibitorami kinaz tyrozynowych oraz przedstawiono możliwości ich prewencji i leczenia w praktyce klinicznej. Świadomość możliwych powikłań sercowo-naczyniowych, regularne monitorowanie, wczesna diagnoza i wdrożenie odpowiedniego leczenia w połączeniu ze ścisłą współpracą z kardiologami może zwiększyć korzyści z długoterminowej terapii tą grupą leków.

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How to Cite
1.
Styczkiewicz K, Sawka D, Styczkiewicz M. Tyrosine kinase inhibitors – should we worry about cardiovascular complications?. OncoReview [Internet]. 2017Apr.2 [cited 2024Nov.23];7(2(26):70-7. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/445
Issue
Vol 7 No 2(26) (2017)
Section
CARDIO-ONCOLOGY
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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