Thrombo-embolic complications related to hormone therapy of breast cancer – a case report Case report

Main Article Content

Szymon Darocha
Sebastian Szmit
Marcin Kurzyna
Łukasz Kownacki

Abstract

69-year old female with breast cancer treated with surgery (total mastectomy) and cheamo- and radiotherapy, with cancer in right breast operated last year, with further hormone therapy with tamoxifen, suffered from low risk pulmonary embolism. She was treated with streptokinase which was complicated by intracerebral bleeding. The patient was referred to the neurosurgeon and conservative treatment was ordered. Than she was transferred to Department of Pulmonary Circulation and Thromboembolic Diseases, ECZ Otwock where vena cava filter was implanted as prevention of recurrence pulmonary embolism. Progression of deep venous thrombosis associated with thrombosis in vena cava filter and the ”resistance” to treatment using enoxaparin was observed. The inclusion of unfractionated heparin in continuous intravenous infusion, withdrawal of tamoxifen and intensification diuretic therapy has improved patient’s status and allowed discharge from hospital.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Article Details

How to Cite
1.
Darocha S, Szmit S, Kurzyna M, Kownacki Łukasz. Thrombo-embolic complications related to hormone therapy of breast cancer – a case report. OncoReview [Internet]. 2013Mar.29 [cited 2024Nov.23];3(1(9):63-8. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/331
Section
Articles

References

1. Falanga A., Zacharski L.: Deep vein thrombosis in cancer: the scale of the problem and approaches to management. Ann. Oncol. 2005; 16: 696-701.
2. Nalluri S.R., Chu D., Keresztes R., Zhu X., Wu S.: Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis. JAMA 2008; 300: 2277-2785.
3. Zangari M., Siegel E., Barlogie B. et al.: Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy. Blood 2002; 100: 1168-1171.
4. Early Breast Cancer Trialists` Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005; 365:1687-1717.
5. Ragaz J., Coldman C.: Survival impact of adjuvant tamoxifen on competing causes of mortality in breast cancer survivors, with analysis of mortality from contralateral breast cancer, cardiovascular events, endometrial cancer, and thromboembolic episodes. J. Clin. Oncol. 1998; 16: 2018-2024.
6. Goldhaber S.Z.: Tamoxifen: preventing breast cancer and placing the risk of deep vein thrombosis in perspective. Circulation 2005; 111: 539-541.
7. Decensi A., Maisonneuve P., Rotmensz N. et al.: Effect of tamoxifen on venous thromboembolic events in a breast cancer prevention trial. Circulation 2005; 111: 650-656.
8. Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) Eur. Heart J. 2008; 29: 2276-2315.
9. Mandala M., Falanga A., Roila F.: Management of venous thromboembolism (VTE) in cancer patients: ESMO Clinical Practice Guidelines. Annals of Oncology 2011; 22(Supp. 6): vi85-vi92.