Targeted therapies in neuroendocrine neoplasms Review article
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Abstract
The primary treatment of gastrointestinal neuroendocrine tumors is surgery, and its extent depends on the clinical stage of cancer. In advanced disease medical therapy is used. One possible form of treatment is biological therapy and radionuclide therapy (PRRT, peptide receptor radionuclide therapy) using radiolabeled somatostatin analogues. The effects of these treatments can improve the combinations of radioactive labeled somatostatin analogues, intra-arterial administered, and the use of radio sensitizing drugs combined with PRRT or PRRT combined with new targeted therapeutic agents such as sunitinib or everolimus. New targeted agents (angiogenesis inhibitors, single and multiple tyrosine kinase inhibitors and new somatostatin analogues, such as pasyreotyd) also evaluated in II and III phase clinical trials. Currently, there are several studies on the efficacy of a combination of different, present and new treatments. PRRT with the combination of sunitinib or everolimus or sequential use of PRRT and one of these compounds may be a promising solution for the treatment of patients with pancreatic endocrine tumors.
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