Invasive fungal infection in a child with Ewing’s sarcoma Case report

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Published: Jan 23, 2016
DOI: https://doi.org/10.5604/01.3001.0009.7393
Keywords:
invasive fungal infection, Candida glabtrata, Ewing's sarcoma, children

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Elżbieta Adamkiewicz-Drożyńska
Department and Clinic of Paediatrics, Haematology and Oncology, Medical University of Gdansk, Poland
Ewa Bień
Department and Clinic of Paediatrics, Haematology and Oncology, Medical University of Gdansk, Poland
Anna Płoszyńska
Department and Clinic of Paediatrics, Haematology and Oncology, Medical University of Gdansk, Poland

Abstract

Invasive fungal infection (IFI) in patients with malignant solid tumours is rare, but it highly increases the risk of cancer recurrence because of prolonged discontinuation of cancer treatment. This paper presents a case of IFI induced by Candida glabrata in a 14-year-old girl with advanced Ewing’s sarcoma and metastases to the bone marrow. She was intensively treated with chemotherapy (CWS, CEVAIE, EWING 2008 + VIDE) and radiotherapy. As the treatment was ineffective, the tumour was surgically removed from the sacrum, and VAI chemotherapy was administered. Due to the symptoms of infection, antifungal treatment was initiated with caspofungin, followed by prophylaxis with posaconazole. In terms of anti-cancer treatment, the patient received megatherapy with auto-HSCT. Signs of infection and gastrotoxic complications developed, which is why broad-spectrum antibiotics and amphotericin B lipid complex were administered. Even so, a multisystem IFI appeared, causing the patient’s death. In multidrug chemotherapy with extended periods of agranulocytosis, primary prevention should be considered, similar to the one offered to patients with haematological malignancies.

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How to Cite
1.
Adamkiewicz-Drożyńska E, Bień E, Płoszyńska A. Invasive fungal infection in a child with Ewing’s sarcoma. OncoReview [Internet]. 2016Jan.23 [cited 2024Nov.23];7(1(25):38-3. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/441
Issue
Vol 7 No 1(25) (2017)
Section
SUPPORTIVE CARE IN ONCOLOGY
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Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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