Targeted therapies for chronic myeloid leukemia and cardiovascular system Review article
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Published:
Oct 1, 2013
Keywords:
imatynib, heart failure, dasatinib, pulmonary arterial hypertension, nilotynib, peripheral arterial occulsive diease
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Abstract
Morbidity of chronic myeloid leukemia is recorded in elderly population, in patients with coexisting significant risk factors for atherosclerosis and heart diseases. Molecularly targeted therapy, imatinib, dasatinib and nilotinib, improve significantly the prognosis. However, the similar molecular targets in the form of different kinases are essential for cardiovascular system and blocking their pathways may have adverse effects. There is evidence about risk of systolic heart failure related to imatinib, pulmonary arterial hypertension induced by dasatinib and ischemic events associated with peripheral arterial disease and observed during nilotinib therapy. Some groups of patients with defined risk factors need appropriate cardiac monitoring.
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Szmit S, Jędrzejczak WW, Torbicki A. Targeted therapies for chronic myeloid leukemia and cardiovascular system. OncoReview [Internet]. 2013Oct.1 [cited 2024Apr.28];3(3(11):163-76. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/340
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