Diagnostics and treatment of acromegaly Review article

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Published: Dec 30, 2011
Keywords:
acromegaly, growth hormone, diagnostic, treatment

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Marek Ruchała
Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewnętrznych Uniwersytetu Medycznego w Poznaniu
Ewelina Szczepanek-Parulska
Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewnętrznych Uniwersytetu Medycznego w Poznaniu
Ewa Komorska-Piotrowiak
Oddział Chorób Wewnętrznych Wojewódzkiego Szpitala Zespolonego w Lesznie

Abstract

Acromegaly is a chronic condition caused by excessive growth hormone secretion and secondary elevation of insulin-like growth factor 1 (IGF-1) concentration. Untreated or inappropriately treated disease results in development of severe complications including increased mortality, decreased average life expectancy and deteriorated quality of life. Constant stimulation of multiple tissues by growth factors in the course of the disease results in a significant increase in the prevalence of both benign and malignant tumors, of which the most frequent are colon, brain, breast, thyroid, uterus, prostate, kidney and skin lesions. All aforementioned complications are more prevalent in subjects with long-lasting and uncontrolled disease, hence an important role of early diagnosis, introduction of adequate treatment and well as careful follow-up in reduction of mortality and improvement of quality of life are discussed in the paper. Moreover, clinical picture of acromegaly, diagnostic procedures as well as up-to-date guidelines regarding therapy and monitoring of patients with this disease are concisely described.

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How to Cite
1.
Ruchała M, Szczepanek-Parulska E, Komorska-Piotrowiak E. Diagnostics and treatment of acromegaly. OncoReview [Internet]. 2011Dec.30 [cited 2024Jul.5];1(4(4):240-7. Available from: https://journalsmededu.pl/index.php/OncoReview/article/view/270
Issue
Vol 1 No 4(4) (2011)
Section
Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright: © Medical Education sp. z o.o. This is an Open Access article distributed under the terms of the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). License (https://creativecommons.org/licenses/by-nc/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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